Storni et al., 2004 - Google Patents
Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effectsStorni et al., 2004
View PDF- Document ID
- 15207940079510626318
- Author
- Storni T
- Ruedl C
- Schwarz K
- Schwendener R
- Renner W
- Bachmann M
- Publication year
- Publication venue
- The Journal of Immunology
External Links
Snippet
DNA rich in nonmethylated CG motifs (CpGs) greatly facilitates induction of immune responses against coadministered Ags. CpGs are therefore among the most promising adjuvants known to date. Nevertheless, CpGs are characterized by two drawbacks. They …
- 239000002245 particle 0 title abstract description 27
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
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- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A61K2039/53—DNA (RNA) vaccination
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