Ratnoff, 1974 - Google Patents
A. The Physiology of Blood CoagulationRatnoff, 1974
- Document ID
- 1442280978747447299
- Author
- Ratnoff O
- Publication year
- Publication venue
- Blood
External Links
Snippet
When mammalian blood is shed, it rapidly transforms into a jelly-like coagulum. This change reflects the conversion of a soluble plasma protein, fibrinogen (factor I) into a network of insoluble fibrin fibers, in whose meshes blood cells and serum are entrapped. The formation …
- 230000023555 blood coagulation 0 title description 38
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0082182B1 (en) | Composition based on the hemostatic agent factor viia and method of preparing same | |
| Marciniak et al. | Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant | |
| JP3701028B2 (en) | How to obtain high purity von Willebrand factor | |
| Niewiarowski et al. | Studies on the adsorption and activation of the Hageman factor (factor XII) by collagen and elastin | |
| US4456591A (en) | Therapeutic method for activating factor VII | |
| JP2540541B2 (en) | Method for producing factor V concentrate | |
| O'Grady et al. | Coagulopathy of fulminant hepatic failure | |
| CZ81997A3 (en) | Pharmaceutical preparation for treating disorders connected with blood clotting, process of its preparation and use | |
| US4479938A (en) | Therapeutic composition containing factor VIIa | |
| Esnouf et al. | Enzymology and the blood clotting mechanism | |
| JPH01193229A (en) | Anticoagulant | |
| US4287180A (en) | Method for treating blood clotting factor inhibitors | |
| Colman et al. | [12] Factor V | |
| US6068838A (en) | Purified multimerase | |
| Esnouf | Biochemistry of blood coagulation | |
| CA1176563A (en) | Therapeutic compositions and methods for manufacture and use | |
| Aronson | Factor IX complex | |
| US4357321A (en) | Method and composition for treating clotting factor inhibitors | |
| US4286056A (en) | Method for making therapeutic enzyme compositions | |
| MAMMEN | Physiology and biochemistry of blood coagulation | |
| Ratnoff | A. The Physiology of Blood Coagulation | |
| Egberg | Coagulation studies in patients treated with Defibrase | |
| US4361510A (en) | Blood coagulation promoting product | |
| Bennett et al. | The normal coagulation mechanism | |
| DAVIE et al. | Molecular mechanisms in blood coagulation |