Nothing Special   »   [go: up one dir, main page]

Yin et al., 2020 - Google Patents

Phosphorylation of myelin regulatory factor by PRKG 2 mediates demyelination in Huntington's disease

Yin et al., 2020

View PDF
Document ID
14096651716784797471
Author
Yin P
Liu Q
Pan Y
Yang W
Yang S
Wei W
Chen X
Hong Y
Bai D
Li X
Li S
Publication year
Publication venue
EMBO reports

External Links

Snippet

Demyelination is a common pathological feature of a large number of neurodegenerative diseases including multiple sclerosis and Huntington's disease (HD). Laquinimod (LAQ) has been found to have therapeutic effects on multiple sclerosis and HD. However, the …
Continue reading at www.embopress.org (PDF) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Hybridisation probes
    • C12Q1/6883—Hybridisation probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Similar Documents

Publication Publication Date Title
Kwon et al. SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models
Huang et al. Differential signaling mediated by ApoE2, ApoE3, and ApoE4 in human neurons parallels Alzheimer's disease risk
Yin et al. Phosphorylation of myelin regulatory factor by PRKG 2 mediates demyelination in Huntington's disease
Berger et al. Localized myosin II activity regulates assembly and plasticity of the axon initial segment
Sen et al. ApoE4 and Aβ oligomers reduce BDNF expression via HDAC nuclear translocation
Li et al. The transcription factor C/EBPβ in the dorsal root ganglion contributes to peripheral nerve trauma–induced nociceptive hypersensitivity
Lian et al. NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer’s disease
Li et al. Cytoplasmic ATM in neurons modulates synaptic function
Suryo Rahmanto et al. FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma
Takao et al. Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia
Li et al. Enzymatic activity of the scaffold protein rapsyn for synapse formation
Sarachana et al. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder
Mo et al. MBD1 contributes to the genesis of acute pain and neuropathic pain by epigenetic silencing of Oprm1 and Kcna2 genes in primary sensory neurons
Volakakis et al. Nurr1 and retinoid X receptor ligands stimulate ret signaling in dopamine neurons and can alleviate α-synuclein disrupted gene expression
de Rosa et al. D‐Aspartate treatment attenuates myelin damage and stimulates myelin repair
Wang et al. UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity and dendritic spine morphology
Jin et al. MeCP2 deficiency in neuroglia: new progress in the pathogenesis of Rett syndrome
Danka Mohammed et al. miR‐204 downregulates EphB2 in aging mouse hippocampal neurons
Lin et al. Melatonin suppresses neuropathic pain via MT2-dependent and-independent pathways in dorsal root ganglia neurons of mice
Cheng et al. SUMO ylation of Me CP 2 is essential for transcriptional repression and hippocampal synapse development
Sun et al. Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model
Wu et al. HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP‐43 proteinopathies
Ran et al. A replication study of GWAS findings in migraine identifies association in a Swedish case–control sample
Wang et al. Activation of hypothalamic RIP‐Cre neurons promotes beiging of WAT via sympathetic nervous system
Fuchs et al. CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signaling