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Zheng et al., 2012 - Google Patents

Development of bone-targeted catalase derivatives for inhibition of bone metastasis of tumor cells in mice

Zheng et al., 2012

Document ID
13912244790293207510
Author
Zheng Y
Nishikawa M
Ikemura M
Yamashita F
Hashida M
Publication year
Publication venue
Journal of pharmaceutical sciences

External Links

Snippet

Removal of hydrogen peroxide by delivering catalase to the vicinity of metastasizing tumor cells is a promising approach for inhibiting tumor metastasis. To inhibit bone metastasis, catalase was conjugated with 3, 5-di (ethylamino-2, 2-bisphosphono) benzoic acid (Bip), a …
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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