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Ambrosini et al., 2013 - Google Patents

Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death

Ambrosini et al., 2013

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Document ID
13910242678131022793
Author
Ambrosini G
Musi E
Ho A
de Stanchina E
Schwartz G
Publication year
Publication venue
Molecular cancer therapeutics

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Oncogenic mutations in GNAQ and GNA11 genes are found in 80% of uveal melanoma. These mutations result in the activation of the RAF/MEK signaling pathway culminating in the stimulation of ERK1/2 mitogen-activated protein kinases. In this study, using a siRNA …
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