Nothing Special   »   [go: up one dir, main page]

Schrecker et al., 1974 - Google Patents

Comparative inhibition of purified DNA polymerases from murine leukemia virus and human lymphocytes by 1-β-D-arabinofuranosylcytosine 5′-triphosphate

Schrecker et al., 1974

Document ID
1380066413387222852
Author
Schrecker A
Smith R
Gallo R
Publication year
Publication venue
Cancer Research

External Links

Snippet

The Km for dCTP and the K1 for 1-β-d-arabinofuranosylcytosine 5′-triphosphate (ara-CTP) were determined with DNA polymerases purified by diethylaminoethyl cellulose and phosphocellulose chromatography from Rauscher murine leukemia virus, from human blood …
Continue reading at aacrjournals.org (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions

Similar Documents

Publication Publication Date Title
Schrecker et al. Comparative inhibition of purified DNA polymerases from murine leukemia virus and human lymphocytes by 1-β-D-arabinofuranosylcytosine 5′-triphosphate
Mao et al. Mode of inhibition of herpes simplex virus DNA polymerase by phosphonoacetate
Chamberlin et al. Deoxyribonucleic acid-directed synthesis of ribonucleic acid by an enzyme from Escherichia coli
Fridland Effect of methotrexate on deoxyribonucleotide pools and DNA synthesis in human lymphocytic cells
Furth et al. Inhibition of mammalian DNA polymerase by the 5′-triphosphate of 1-β-d-arabinofuranosylcytosine and the 5′-triphosphate of 9-β-d-arabinofuranosyladenine
Bloch et al. On the mode of action of 7-deaza-adenosine (tubercidin)
Gratecos et al. Adenosine 5′-0 (3-thiotriphosphate) in the control of phosphorytase activity
Gray et al. Studies on the biosynthesis of deoxyribonucleic acid by extracts of mammalian cells V. Factors interferring with biosynthesis
Plowman et al. A kinetic study of nucleotide interactions with pyruvate kinase
Cardeilhac et al. Some metabolic properties of nucleotides of 1-β-d-arabinofuranosylcytosine
Lee et al. Kinetic studies on phosphorylation of 5-azacytidine with the purified uridine-cytidine kinase from calf thymus
Lewis et al. Mammalian DNA Polymerases. alpha.,. beta.,. gamma.,. delta., and. epsilon. Incorporate Fialuridine (FIAU) Monophosphate into DNA and Are Inhibited Competitively by FIAU Triphosphate
Matsukage et al. Inhibitory effect of 1-β-D-arabinofuranosylthymine 5′-triphosphate and 1-β-D-arabinofuranosylcytosine 5′-triphosphate on DNA polymerases from murine cells and oncornavirus
Dube et al. Manganese as a mutagenic agent during in vitro DNA synthesis
Gefter et al. Deoxyribonucleic Acid Synthesis in Cell-free Extracts: III. CATALYTIC PROPERTIES OF DEOXYRIBONUCLEIC ACID POLYMERASE II
Ono et al. Inhibitory effects of 9-β-D-arabinofuranosylguanine 5′-triphosphate and 9-β-D-arabinofuranosyladenine 5′-triphosphate on DNA polymerases from murine cells and oncornavirus
Bujard et al. Fluorinated pyrimidines. XXVII. Attempts to determine transcription errors during the formation of fluorouracil-containing messenger ribonucleic acid
Gallo et al. The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes: IV. Comparisons between normal and leukemic leukocytes
Brown et al. Release of nuclear DNA template restrictions by specific polyribonucleotides
Cass 9-β-D-arabinofuranosyladenine (AraA)
Momparler et al. Enzymatic estimation and metabolism of 1-β-d-arabinofuranosylcytosine in man
SLATER et al. DNA polymerase potentials of sea urchin embryos
Sy et al. Purification and properties of guanosine 5', 3'-polyphosphate synthetase from Bacillus brevis
Schrecker et al. Inhibition of RNA-dependent DNA polymerase by thymidylate derivatives
Kozai et al. Enzymatic Phosphorylation of 1-β-d-Arabinofuranosylcytosine