Gu et al., 2016 - Google Patents
Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosisGu et al., 2016
View HTML- Document ID
- 1371852640476988658
- Author
- Gu H
- Fisher A
- Mickler E
- Duerson III F
- Cummings O
- Peters-Golden M
- Twigg III H
- Woodruff T
- Wilkes D
- Vittal R
- Publication year
- Publication venue
- The FASEB Journal
External Links
Snippet
Complement activation, an integral arm of innate immunity, may be the critical link to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Whereas we have previously reported elevated anaphylatoxins—complement component 3a (C3a) and complement component …
- 101700049499 C5AR1 0 title abstract description 97
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Hybridisation probes
- C12Q1/6883—Hybridisation probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Gu et al. | Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis | |
Takemasa et al. | A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice | |
Chen et al. | ELABELA and an ELABELA fragment protect against AKI | |
Kolb et al. | Proteoglycans decorin and biglycan differentially modulate TGF-β-mediated fibrotic responses in the lung | |
Chrysanthopoulou et al. | Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension | |
Lee et al. | Impaired wound healing and angiogenesis in eNOS-deficient mice | |
Kim et al. | Progressive cellular senescence mediates renal dysfunction in ischemic nephropathy | |
Nold-Petry et al. | IL-32 promotes angiogenesis | |
Naik et al. | Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis | |
Yang et al. | Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1 | |
Sidhu et al. | Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma | |
Gu et al. | Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis | |
Khan et al. | EDB fibronectin and angiogenesis–a novel mechanistic pathway | |
Wu et al. | Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion-induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO-1 signaling | |
Short et al. | IL‐10 promotes endothelial progenitor cell infiltration and wound healing via STAT3 | |
Zhou et al. | FPR1 gene silencing suppresses cardiomyocyte apoptosis and ventricular remodeling in rats with ischemia/reperfusion injury through the inhibition of MAPK signaling pathway | |
Zhang et al. | Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds | |
Lin et al. | Yin yang 1 is a novel regulator of pulmonary fibrosis | |
Montgomery et al. | Breast regression protein–39/chitinase 3–like 1 promotes renal fibrosis after kidney injury via activation of myofibroblasts | |
Ghatak et al. | Overexpression of c-Met and CD44v6 receptors contributes to autocrine TGF-β1 signaling in interstitial lung disease | |
JP2009501521A (en) | Methods for diagnosing and treating inflammatory responses | |
AU2008275678A1 (en) | Treatment and diagnostic methods for fibrosis related disorders | |
Brand et al. | Transforming growth factor-β and interleukin-1β signaling pathways converge on the chemokine CCL20 promoter | |
Lee et al. | Laminin α1 is a genetic modifier of TGF-β1–stimulated pulmonary fibrosis | |
Kim et al. | Upregulated stromal cell-derived factor 1 (SDF-1) expression and its interaction with CXCR4 contribute to the pathogenesis of severe pterygia |