Brinkman et al., 2016 - Google Patents
Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancerBrinkman et al., 2016
View HTML- Document ID
- 13714396653734215270
- Author
- Brinkman A
- Chen G
- Wang Y
- Hedman C
- Sherer N
- Havighurst T
- Gong S
- Xu W
- Publication year
- Publication venue
- Biomaterials
External Links
Snippet
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer for which there is no available targeted therapy. TNBC cases contribute disproportionately to breast cancer-related mortality, thus the need for novel and effective therapeutic methods is urgent …
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 FC=1C(C)=C(F)C(N)=C(C(C=2)=O)C=1OC=2C1=CC=C(N)C(F)=C1 0 title abstract description 203
Classifications
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