Nothing Special   »   [go: up one dir, main page]

Gharaee-Kermani et al., 1998 - Google Patents

The role of IL-5 in bleomycin-induced pulmonary fibrosis

Gharaee-Kermani et al., 1998

View PDF
Document ID
13396079146984518337
Author
Gharaee-Kermani M
McGarry B
Lukacs N
Huffnagle G
Egan R
Phan S
Publication year
Publication venue
Journal of leukocyte biology

External Links

Snippet

Eosinophils are known to express cytokines capable of promoting fibrosis. Interleukin-5 (IL- 5) is important in regulating eosinophilopoiesis, eosinophil recruitment and activation. Lung IL-5 expression is elevated in pulmonary fibrosis, wherein the eosinophil is a primary source …
Continue reading at jlb.onlinelibrary.wiley.com (PDF) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2026—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Similar Documents

Publication Publication Date Title
Gharaee-Kermani et al. The role of IL-5 in bleomycin-induced pulmonary fibrosis
Zhang et al. TNF-alpha-mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis.
Tager et al. Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10
Huaux et al. Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis
Smith et al. TNF and IL-6 mediate MIP-1α expression in bleomycin-induced lung injury
Stahl et al. Increased expression of monocyte chemoattractant protein-1 in anti-thymocyte antibody-induced glomerulonephritis
Eming et al. Accelerated wound closure in mice deficient for interleukin-10
Gharaee-Kermani et al. CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis
Cooper et al. IL-1 activity is reduced in psoriatic skin. Decreased IL-1 alpha and increased nonfunctional IL-1 beta.
Rolfe et al. Pulmonary fibroblast expression of interleukin-8: a model for alveolar macrophage-derived cytokine networking
Schnyder-Candrian et al. Interleukin-17 is a negative regulator of established allergic asthma
Nagai et al. Interferon-γ and tumor necrosis factor-α protect mice from invasive aspergillosis
Tetta et al. Tumour necrosis factor in serum and synovial fluid of patients with active and severe rheumatoid arthritis.
Williams et al. Monocyte anergy in septic shock is associated with a predilection to apoptosis and is reversed by granulocyte-macrophage colony-stimulating factor ex vivo
Martinet et al. Differential expression of the tumor necrosis factor/cachectin gene by blood and lung mononuclear phagocytes
Wang et al. By homing to the kidney, activated macrophages potently exacerbate renal injury
Rolfe et al. Expression and regulation of human pulmonary fibroblast-derived monocyte chemotactic peptide-1
Pechkovsky et al. CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II
Suga et al. CXCR3 deficiency prolongs Th1-type contact hypersensitivity
US20080175815A1 (en) Methods and products for modulation of reproductive processes and for diagnosis, prognostication and treatment or related conditions
JP2011219501A (en) Cytokine use; composition; method
Christensen et al. Role of diminished epithelial GM-CSF in the pathogenesis of bleomycin-induced pulmonary fibrosis
Hogmalm et al. β6 integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia
Karkar et al. Abrogation of glomerular injury in nephrotoxic nephritis by continuous infusion of interleukin-6
Hirayama et al. Cytokine mRNA expression of bone marrow stromal cells from patients with aplastic anaemia and myelodysplastic syndrome