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Guo et al., 2016 - Google Patents

The analgesic effect of rolipram is associated with the inhibition of the activation of the spinal astrocytic JNK/CCL2 pathway in bone cancer pain

Guo et al., 2016

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Document ID
13179461875941767770
Author
Guo C
Bai L
Wu H
Yang J
Cai G
Wang X
Wu S
Ma W
Publication year
Publication venue
International Journal of Molecular Medicine

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Snippet

Bone cancer pain (BCP) is one of the most difficult and intractable tasks for pain management, which is associated with spinal 'neuron-astrocytic'activation. The activation of the c-Jun N-terminal kinase (JNK)/chemokine (CC motif) ligand (CCL2) signaling pathway …
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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