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Obermann et al., 2024 - Google Patents

Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH

Obermann et al., 2024

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Document ID
12593401961336927730
Author
Obermann T
Sakshaug T
Kanagaraj V
Abentung A
Sarno A
Bjørås M
Scheffler K
Publication year
Publication venue
bioRxiv

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Snippet

8-oxo-7, 8-dihydroguanine (OG) is one of the most abundant oxidative lesions in the genome and associated with genome instability. Its mutagenic potential is counteracted by a concerted action of 8-oxoguanine DNA glycosylase (OGG1) and mutY homolog DNA …
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