Nothing Special   »   [go: up one dir, main page]

Homma et al., 1992 - Google Patents

Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl) adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive …

Homma et al., 1992

Document ID
12266999144120172856
Author
Homma H
Watanabe Y
Abiru T
Murayama T
Nomura Y
Matsuda A
Publication year
Publication venue
Journal of medicinal chemistry

External Links

Snippet

Chemical modificationsof the potent A2 adenosine receptor agonist 2-(l-hexyn-l-yl) adenosine (7, 2-HA) at the S'-position have been carried out to find more potent andselective A2 agonists. These analogues were evaluated for adenosine and A2 receptor …
Continue reading at pubs.acs.org (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Similar Documents

Publication Publication Date Title
Homma et al. Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl) adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity
FI93217B (en) Process for the preparation of esters and amides of therapeutically active nucleoside derivatives
Matsuda et al. Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects
ES2201552T3 (en) ADENOSINE RECEIVER A1 AGONISTS.
DK170893B1 (en) New 5'-deoxy-5-fluorocytidine derivatives, a process for the preparation thereof, pharmaceutical agents containing such derivatives and the use of the derivatives to prepare an antitumor agent
Watanabe et al. Synthesis and anti-HIV-1 activity of 2'-" up"-fluoro analogs of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2', 3'-dideoxycytidine (DDC)
WO2003062256A1 (en) 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
CA2685748A1 (en) Azido purine nucleosides for treatment of viral infections
FI81587B (en) FOERFARANDE FOER FRAMSTAELLNING AV FARMACEUTISKT ANVAENDBARA N6-SUBSTITUERADE DEOXIRIBOSANALOGER AV ADENOSINER.
CA3085337A1 (en) Cyclic dinucleotides as sting agonists
WO2011005595A2 (en) 2-5a analogs and their methods of use
US20020150936A1 (en) Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
WO2010068708A2 (en) 3'-azido purine nucleotide prodrugs for treatment of viral infections
FI77666B (en) FOERFARANDE FOER FRAMSTAELLNING AV PHARMACEUTISKT ANVAENDBARA N6-SUBSTITUERADE ADENOSINER.
Gawin et al. Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure
CN102285969B (en) N-1-substituted piperidin-4-arylamine derivatives and preparation method and use thereof
US5229505A (en) N6 -[3-(1-substituted)indolylethyl] adenosine 5'-carboxamides and their pharmaceutical compositions
WO2003053989A1 (en) Masked phosphate containing nucleoside derivatives and their use as antivirals
AU616914B2 (en) Therapeutic necleosides
DE68918036T2 (en) Nucleoside derivatives.
Zhang et al. Synthesis of neplanocin F analogues as potential antiviral agents
CA1262898A (en) 2,n.sup.6-substituted adenosines derivatives and methods of use
Narayanasamy et al. Synthesis and anti-HIV activity of (−)-β-d-(2R, 4R)-1, 3-dioxolane-2, 6-diamino purine (DAPD)(amdoxovir) and (−)-β-d-(2R, 4R)-1, 3-dioxolane guanosine (DXG) prodrugs
Wang et al. Synthesis and in vitro anti-hepatitis B virus activity of six-membered azanucleoside analogues
JPH0692986A (en) Substituted nucleoside derivative, its production and medicinal composition containing it