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Mircetic et al., 2017 - Google Patents

Development of a genetic sensor that eliminates p53 deficient cells

Mircetic et al., 2017

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Document ID
12177586994238931762
Author
Mircetic J
Dietrich A
Paszkowski-Rogacz M
Krause M
Buchholz F
Publication year
Publication venue
Nature communications

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Snippet

The TP53 gene fulfills a central role in protecting cells from genetic insult. Given this crucial role it might be surprising that p53 itself is not essential for cell survival. Indeed, TP53 is the single most mutated gene across different cancer types. Thus, both a theoretical and a …
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