Popescu et al., 2016 - Google Patents
Injectable hydrogel: Amplifying the pH sensitivity of a triblock copolypeptide by conjugating the N-termini via dynamic covalent bondingPopescu et al., 2016
- Document ID
- 11991957142407434275
- Author
- Popescu M
- Liontos G
- Avgeropoulos A
- Voulgari E
- Avgoustakis K
- Tsitsilianis C
- Publication year
- Publication venue
- ACS Applied Materials & Interfaces
External Links
Snippet
We explore the self-assembly behavior of aqueous solutions of an amphiphilic, pH-sensitive poly (l-alanine)-b-poly (l-glutamic acid)-b-poly (l-alanine),(A5E11A5) triblock copolypeptide, end-capped by benzaldehyde through Schiff base reaction. At elevated concentrations and …
- 239000000017 hydrogel 0 title abstract description 219
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/30—Macromolecular compounds
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin, zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/30—Macromolecular compounds
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, copolymers of polyalkylene glycol or poloxamer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/48—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K8/00—Cosmetic or similar toilet preparations
- A61K8/18—Cosmetic or similar toilet preparations characterised by the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ghosh et al. | pH-responsive biocompatible supramolecular peptide hydrogel | |
| Popescu et al. | Injectable hydrogel: Amplifying the pH sensitivity of a triblock copolypeptide by conjugating the N-termini via dynamic covalent bonding | |
| Liarou et al. | Smart polymersomes and hydrogels from polypeptide-based polymer systems through α-amino acid N-carboxyanhydride ring-opening polymerization. From chemistry to biomedical applications | |
| Cao et al. | Reversible thermoresponsive peptide–PNIPAM hydrogels for controlled drug delivery | |
| Bauri et al. | Amino acid-derived stimuli-responsive polymers and their applications | |
| Gu et al. | Hydrogels with smart systems for delivery of hydrophobic drugs | |
| Song et al. | Thermoresponsive hydrogel induced by dual supramolecular assemblies and its controlled release property for enhanced anticancer drug delivery | |
| Bikram et al. | Thermo-responsive systems for controlled drug delivery | |
| Holowka et al. | Charged polypeptide vesicles with controllable diameter | |
| MacKay et al. | Quantitative model of the phase behavior of recombinant pH-responsive elastin-like polypeptides | |
| Zhao et al. | A review of polypeptide-based polymersomes | |
| Mikhalevich et al. | Amphiphilic peptide self-assembly: expansion to hybrid materials | |
| Li et al. | Stimuli-responsive polymer vesicles | |
| Lu et al. | Injectable shear-thinning hydrogels engineered with a self-assembling Dock-and-Lock mechanism | |
| Meng et al. | Polymersomes spanning from nano-to microscales: advanced vehicles for controlled drug delivery and robust vesicles for virus and cell mimicking | |
| Christian et al. | Polymersome carriers: from self-assembly to siRNA and protein therapeutics | |
| Sun et al. | Direct formation of giant vesicles from synthetic polypeptides | |
| Wong et al. | Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications | |
| Augustine et al. | pH-responsive polypeptide-based smart nano-carriers for theranostic applications | |
| Desai et al. | Synthesis and characterization of photocurable polyamidoamine dendrimer hydrogels as a versatile platform for tissue engineering and drug delivery | |
| Aluri et al. | Multistimuli-responsive amphiphilic poly (ester-urethane) nanoassemblies based on L-tyrosine for intracellular drug delivery to cancer cells | |
| Morell et al. | Hybrid block copolymers constituted by peptides and synthetic polymers: An overview of synthetic approaches, supramolecular behavior and potential applications | |
| Rahman et al. | Spontaneous formation of gating lipid domain in uniform-size peptide vesicles for controlled release | |
| Liu et al. | Molecular bases for temperature sensitivity in supramolecular assemblies and their applications as thermoresponsive soft materials | |
| Yu et al. | Injectable thermosensitive polypeptide-based CDDP-complexed hydrogel for improving localized antitumor efficacy |