Nothing Special   »   [go: up one dir, main page]

Luker, 1993 - Google Patents

Structure-activity correlation for tracheal cytotoxin: defining a novel muramyl peptide interaction site

Luker, 1993

Document ID
11834957620892358714
Author
Luker K
Publication year

External Links

Snippet

Despite the availability of a highly effective vaccine, whooping cough, or pertussis, remains a global problem and a persistent clinical challenge. In the US, pertussis is a significant cause of childhood illness. Although antibiotic therapy eliminates the infecting organisms …
Continue reading at search.proquest.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Similar Documents

Publication Publication Date Title
US5371186A (en) Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock
Chamberlain et al. Major integral membrane protein immunogens of Treponema pallidum are proteolipids
Luker et al. Tracheal cytotoxin structural requirements for respiratory epithelial damage in pertussis
Luker et al. Bordetella pertussis tracheal cytotoxin and other muramyl peptides: distinct structure-activity relationships for respiratory epithelial cytopathology.
Nowicki et al. A hemagglutinin of uropathogenic Escherichia coli recognizes the Dr blood group antigen
IE83655B1 (en) Synthetic peptides for detoxification of bacterial endotoxins and treatment of septic shock
DE69630457T2 (en) CONNECTIONS TO IMMUNOTHERAPY AND DIAGNOSIS OF TUBERCULOSIS
US3778426A (en) Therapeutically useful polypeptides
US6114310A (en) Efflux pump inhibitors
JP2660161B2 (en) Actinoplanes sp. Having pharmacological activity -Derived lipopeptide, method for producing the same and use thereof
USRE32311E (en) Derivatives of A-21978C cyclic peptides
Nagai et al. Structural specificity of synthetic peptide adjuvant for induction of experimental allergic encephalomyelitis
US6573242B1 (en) Dihydroxypropyl cysteine peptide and agent containing this peptide
Luker Structure-activity correlation for tracheal cytotoxin: defining a novel muramyl peptide interaction site
Jiwa Enterotoxigenicity, hemagglutination and cell-surface hydrophobicity in Aeromonas hydrophila, A. sobria and A. salmonicida
Weinberg et al. Lipoproteins of Haemophilus influenzae type b
Wu et al. Biogenesis of membrane lipoproteins in Escherichia coli
US4396543A (en) Derivatives of A-21978C cyclic peptides
JPH01311093A (en) Substituted n-glycosylamides
Nagao et al. Structural requirements of muramylpeptides for induction of necrosis at sites primed with Mycobacterium tuberculosis in guinea pigs
Bahr et al. Analysis of the antigenic relationship of various derivatives of n-acetyl-muramyl-l-ala-d-isoglutamine (MDP), using anti-MDP antibodies
CA2258487A1 (en) Cyclic depsipeptides and drugs containing the same as the active ingredient
US4957736A (en) Composition for vaccines
IE64444B1 (en) New adamantyl comprising tripeptides derivatives and hydrochlorides thereof their preparation and use
Saelinger ADPribosylating enzymes as virulence factors