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Han et al., 2020 - Google Patents

Modularly designed peptide nanoprodrug augments antitumor immunity of PD-L1 checkpoint blockade by targeting indoleamine 2, 3-dioxygenase

Han et al., 2020

Document ID
11764336098227230049
Author
Han X
Cheng K
Xu Y
Wang Y
Min H
Zhang Y
Zhao X
Zhao R
Anderson G
Ren L
Nie G
Li Y
Publication year
Publication venue
Journal of the American Chemical Society

External Links

Snippet

The limited efficacy of single-agent immune checkpoint inhibitors in treating tumors has prompted investigations on their combination partners. Here, a tumor-homing indoleamine 2, 3-dioxygenase (IDO) nanoinhibitor is reported to selectively inhibit immunosuppressive …
Continue reading at pubs.acs.org (other versions)

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    • A61K47/48892Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the conjugate being characterized by a special physical or galenical form the form being a particulate, powder, adsorbate, bead, sphere the form being a solid micro- or nanoparticle having no hollow or gas-filled core the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
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