Thomas et al., 2021 - Google Patents
A novel strain-specific neutralizing epitope on glycoprotein H of Human CytomegalovirusThomas et al., 2021
View PDF- Document ID
- 10922833117247404476
- Author
- Thomas M
- Kropff B
- Schneider A
- Winkler T
- Görzer I
- Sticht H
- Britt W
- Mach M
- Reuter N
- Publication year
- Publication venue
- Journal of Virology
External Links
Snippet
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe clinical disease in immunosuppressed patients and congenitally infected newborn infants. Viral envelope glycoproteins represent attractive targets for vaccination or passive …
- 241000701024 Human betaherpesvirus 5 0 title abstract description 21
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses, e.g. hepatitis E virus
- C07K16/1036—Retroviridae, e.g. leukemia viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/088—Varicella-zoster virus, e.g. cytomegalovirus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA Viruses
- C12N2710/00011—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA Viruses dsDNA Viruses
- C12N2710/16011—Herpesviridae
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Pötzsch et al. | B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies | |
Shimamura et al. | Human cytomegalovirus infection elicits a glycoprotein M (gM)/gN-specific virus-neutralizing antibody response | |
Bootz et al. | Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus | |
Kropff et al. | Glycoprotein N of human cytomegalovirus protects the virus from neutralizing antibodies | |
Lilleri et al. | Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection | |
Kauvar et al. | A high-affinity native human antibody neutralizes human cytomegalovirus infection of diverse cell types | |
Ha et al. | Neutralization of diverse human cytomegalovirus strains conferred by antibodies targeting viral gH/gL/pUL128-131 pentameric complex | |
Mach et al. | Complex formation by human cytomegalovirus glycoproteins M (gpUL100) and N (gpUL73) | |
Vanarsdall et al. | Human cytomegalovirus glycoproteins gB and gH/gL mediate epithelial cell-cell fusion when expressed either in cis or in trans | |
Cui et al. | Impact of antibodies and strain polymorphisms on cytomegalovirus entry and spread in fibroblasts and epithelial cells | |
Auerbach et al. | A neutralizing anti-gH/gL monoclonal antibody is protective in the guinea pig model of congenital CMV infection | |
Li et al. | Complement enhances in vitro neutralizing potency of antibodies to human cytomegalovirus glycoprotein B (gB) and immune sera induced by gB/MF59 vaccination | |
Spindler et al. | Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus | |
Wiegers et al. | Identification of a neutralizing epitope within antigenic domain 5 of glycoprotein B of human cytomegalovirus | |
Thomas et al. | A novel strain-specific neutralizing epitope on glycoprotein H of Human Cytomegalovirus | |
Patel et al. | In vitro characterization of human cytomegalovirus-targeting therapeutic monoclonal antibodies LJP538 and LJP539 | |
Kawabata et al. | Analysis of a neutralizing antibody for human herpesvirus 6B reveals a role for glycoprotein Q1 in viral entry | |
Sato et al. | Identification of the region including the epitope for a monoclonal antibody which can neutralize human parvovirus B19 | |
Ye et al. | Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step | |
Reuter et al. | Cell fusion induced by a fusion-active form of human cytomegalovirus glycoprotein B (gB) is inhibited by antibodies directed at antigenic domain 5 in the ectodomain of gB | |
Lee et al. | Structural analysis of the Kaposi's sarcoma-associated herpesvirus K1 protein | |
Coleman et al. | A homolog pentameric complex dictates viral epithelial tropism, pathogenicity and congenital infection rate in guinea pig cytomegalovirus | |
TW202248210A (en) | Antibody-mediated neutralization of chikungunya virus | |
Oyaizu et al. | Complementation of the function of glycoprotein H of human herpesvirus 6 variant A by glycoprotein H of variant B in the virus life cycle | |
Powell et al. | Human monoclonal antibodies against Ross River virus target epitopes within the E2 protein and protect against disease |