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KOBAYASHI, 2021 - Google Patents

Identification and Characterization of Cancer Stem Cells Responsible for Drug-Resistance and Metastasis

KOBAYASHI, 2021

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Document ID
10742073047225688241
Author
KOBAYASHI S
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In the normal intestine, LGR5 is initially identified as a marker of normal stem cells (Barker et al., 2007), and LGR5 activates the WNT signaling pathway by binding its ligand, R-spondin. The WNT signaling pathway plays a crucial role in tissue generation, and the WNT activation …
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N2510/00—Genetically modified cells
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