Kanda et al., 2020 - Google Patents
Deterministic paracrine repair of injured myocardium using microfluidic-based cocooning of heart explant-derived cellsKanda et al., 2020
- Document ID
- 10226427028565373090
- Author
- Kanda P
- Benavente-Babace A
- Parent S
- Connor M
- Soucy N
- Steeves A
- Lu A
- Cober N
- Courtman D
- Variola F
- Alarcon E
- Liang W
- Stewart D
- Godin M
- Davis D
- Publication year
- Publication venue
- Biomaterials
External Links
Snippet
While encapsulation of cells within protective nanoporous gel cocoons increases cell retention and pro-survival integrin signaling, the influence of cocoon size and intra-capsular cell-cell interactions on therapeutic repair are unknown. Here, we employ a microfluidic …
- 210000002216 Heart 0 title abstract description 26
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kanda et al. | Deterministic paracrine repair of injured myocardium using microfluidic-based cocooning of heart explant-derived cells | |
| Mastikhina et al. | Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing | |
| Maumus et al. | Mesenchymal stem cell-derived extracellular vesicles: opportunities and challenges for clinical translation | |
| Ding et al. | Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges | |
| Cabral et al. | Extracellular vesicles as modulators of wound healing | |
| Zhao et al. | Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction | |
| Xue et al. | Exosomes derived from hypoxia-treated human adipose mesenchymal stem cells enhance angiogenesis through the PKA signaling pathway | |
| Rautiainen et al. | Angiogenic effects and crosstalk of adipose-derived mesenchymal stem/stromal cells and their extracellular vesicles with endothelial cells | |
| Pourakbari et al. | The potential of exosomes in the therapy of the cartilage and bone complications; emphasis on osteoarthritis | |
| Yoon et al. | Enhanced cartilage formation via three-dimensional cell engineering of human adipose-derived stem cells | |
| Daquinag et al. | Adipose tissue engineering in three-dimensional levitation tissue culture system based on magnetic nanoparticles | |
| Hsiao et al. | Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue | |
| RU2515156C2 (en) | Methods of treating inflammatory diseases of colon | |
| Jeong et al. | Nanovesicles engineered from ES cells for enhanced cell proliferation | |
| JP4971787B2 (en) | Use of adipose tissue-derived cells in the treatment of cardiovascular disease | |
| Yao et al. | Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders | |
| Zhang et al. | Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases | |
| Khazaei et al. | Exosomes and exosome-loaded scaffolds: characterization and application in modern regenerative medicine | |
| WO2011069121A1 (en) | Mesenchymal stem cells (mscs) isolated from mobilized peripheral blood | |
| Alderfer et al. | Harnessing biomaterials for lymphatic system modulation | |
| Sun et al. | A 3D culture system improves the yield of MSCs-derived extracellular vesicles and enhances their therapeutic efficacy for heart repair | |
| Hammel et al. | Engineering in vitro immune-competent tissue models for testing and evaluation of therapeutics | |
| Xue et al. | miR-371b-5p-engineered exosomes enhances tumor inhibitory effect | |
| Chen et al. | Directional homing of glycosylation-modified bone marrow mesenchymal stem cells for bone defect repair | |
| Zheng et al. | Production and biological effects of extracellular vesicles from adipose-derived stem cells were markedly increased by low-intensity ultrasound stimulation for promoting diabetic wound healing |