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Qian et al., 2021 - Google Patents

Periodontitis deteriorates cognitive function and impairs neurons and glia in a mouse model of Alzheimer's disease

Qian et al., 2021

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Document ID
9776902708771225538
Author
Qian X
Zhang S
Duan L
Yang F
Zhang K
Yan F
Ge S
Publication year
Publication venue
Journal of Alzheimer’s Disease

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Snippet

Background: Although periodontitis is reportedly associated with increased cognitive decline in Alzheimer's disease, the mechanisms underlying this process remain unknown. Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) is an endotoxin associated with …
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
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    • A61K31/47Quinolines; Isoquinolines
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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