Nothing Special   »   [go: up one dir, main page]

Morrison et al., 1987 - Google Patents

Transfectomas Provide Antibodies with Novel Structures and Functions

Morrison et al., 1987

Document ID
9719028037229063814
Author
Morrison S
Wims L
Gregor P
Kobrin B
Oi V
Publication year
Publication venue
Antibodies: Structure, Synthesis, Function, and Immunologic Intervention in Disease

External Links

Snippet

The importance of antibodies in providing specific protection against disease has long been recognized. Antibodies can neutralize the effects of bacterial toxins, such as those causing tetanus and diptheria, can facilitate the killing of pathogenic bacteria, and can protect …
Continue reading at link.springer.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material Not used, see subgroups
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells

Similar Documents

Publication Publication Date Title
Morrison Transfectomas provide novel chimeric antibodies
EP0256654B1 (en) Chimeric murine/human immunoglobulin specific for tumour-associated 17-1A Antigen
Gillies et al. High-level expression of chimeric antibodies using adapted cDNA variable region cassettes
US4978745A (en) Immunoreactive heterochain antibodies
US5807715A (en) Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
AU606320B2 (en) Modular assembly of antibody genes, antibodies prepared thereby and use
Morrison et al. Genetically engineered antibody molecules
EP0171496B1 (en) Process for the production of a chimera monoclonal antibody
Gascoigne et al. Secretion of a chimeric T-cell receptor-immunoglobulin protein.
KR0164608B1 (en) Production of antibodies from transgenic animals
EP0436016B1 (en) Chimeric anti-cea antibody
Tan et al. A human-mouse chimeric immunoglobulin gene with a human variable region is expressed in mouse myeloma cells.
AU634314B2 (en) Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen
JP2001095566A (en) Immunoconjugate of cytokine
JPH02501191A (en) Recombinant antibodies and methods
JPH06506927A (en) Minimum identification unit of PEM mucin tandem repeat sequence-specific monoclonal antibody
JPH02503143A (en) Chimeric antibody specific for human B cell surface antigen
PT100195B (en) QUIMERIC AND HUMAN MONOCLONAL ANTIBODIES CONNECTING EPIDERME GROWTH FACTOR RECEPTOR EPITHOPES, ITS EXPRESSION VECTORS, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
Shearman et al. Construction, expression and characterization of humanized antibodies directed against the human alpha/beta T cell receptor.
EP0511308B1 (en) Chimeric immunoglobulin for cd4 receptors
EP0404003A2 (en) Chimeric mouse-human KM10 antibody with specificity to a human tumor cell antigen
Morrison et al. Genetically engineered antibody molecules: new tools for cancer therapy
Morrison et al. Transfectomas Provide Antibodies with Novel Structures and Functions
Morrison et al. SECTION V IMMUNOLOGIC INTERVENTION WITH MONOCLONAL ANTIBODIES
Köhler et al. Different ways to modify monoclonal antibodies