Nothing Special   »   [go: up one dir, main page]

Seesuay et al., 2021 - Google Patents

Human transbodies to reverse transcriptase connection subdomain of HIV-1 gag-pol polyprotein reduce infectiousness of the virus progeny

Seesuay et al., 2021

View HTML
Document ID
9655785579055495893
Author
Seesuay W
Phanthong S
Densumite J
Mahasongkram K
Sookrung N
Chaicumpa W
Publication year
Publication venue
Vaccines

External Links

Snippet

HIV-1 progeny are released from infected cells as immature particles that are unable to infect new cells. Gag-Pol polyprotein dimerization via the reverse transcriptase connection domain (RTCDs) is pivotal for proper activation of the virus protease (PR protein) in an early …
Continue reading at www.mdpi.com (HTML) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay
    • G01N33/569—Immunoassay; Biospecific binding assay for micro-organisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse Transcribing RNA Viruses
    • C12N2740/00011—Reverse Transcribing RNA Viruses
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses

Similar Documents

Publication Publication Date Title
Gushchin et al. Neutralizing activity of sera from Sputnik V-vaccinated people against variants of concern (VOC: B. 1.1. 7, B. 1.351, P. 1, B. 1.617. 2, B. 1.617. 3) and Moscow endemic SARS-CoV-2 variants
Kim et al. The impact on infectivity and neutralization efficiency of SARS-CoV-2 lineage B. 1.351 pseudovirus
Lai Small molecule HIV-1 attachment inhibitors: discovery, mode of action and structural basis of inhibition
Dassanayake et al. Molecular docking and in-silico analysis of natural biomolecules against dengue, ebola, zika, SARS-CoV-2 variants of concern and monkeypox virus
Yarovaya et al. Borneol ester derivatives as entry inhibitors of a wide spectrum of SARS-CoV-2 viruses
Lee et al. Identification of entry inhibitors against delta and omicron variants of SARS-CoV-2
Su et al. Reviewing HIV-1 Gag mutations in protease inhibitors resistance: insights for possible novel Gag inhibitor designs
Aguilar-Hernández et al. Protein disulfide isomerase A4 is involved in genome uncoating during human astrovirus cell entry
Panya et al. A synthetic bioactive peptide derived from the asian medicinal plant Acacia Catechu binds to dengue virus and inhibits cell entry
Borisevich et al. Simulation of Molecular Dynamics of SARS-CoV-2 S-Protein in the Presence of Multiple Arbidol Molecules: Interactions and Binding Mode Insights
Fricke et al. Antibodies targeting KSHV gH/gL reveal distinct neutralization mechanisms
Su et al. Adding an Artificial Tail—Anchor to a Peptide-Based HIV-1 Fusion Inhibitor for Improvement of Its Potency and Resistance Profile
Khlusevich et al. New p35 (H3L) epitope involved in vaccinia virus neutralization and its deimmunization
Emmelot et al. SARS-CoV-2 omicron BA. 4/BA. 5 mutations in spike leading to T cell escape in recently vaccinated individuals
Shahid et al. An engineered microvirin variant with identical structural domains potently inhibits human immunodeficiency virus and hepatitis C virus cellular entry
Zhang et al. Identification and characterization of a novel epitope of ASFV-encoded dUTPase by monoclonal antibodies
Seesuay et al. Human transbodies to reverse transcriptase connection subdomain of HIV-1 gag-pol polyprotein reduce infectiousness of the virus progeny
Friedrich et al. Glutamic acid residues in HIV-1 p6 regulate virus budding and membrane association of Gag
Lu et al. An intracellular epitope of ASFV cd2v protein elicits humoral and cellular immune responses
França et al. New anti-flavivirus fusion loop human antibodies with zika virus-neutralizing potential
Álvarez et al. Unveiling the multifaceted roles of ISG15: from immunomodulation to therapeutic frontiers
Yamaoka et al. Characterization and utilization of disulfide-bonded SARS-CoV-2 receptor binding domain of spike protein synthesized by wheat germ cell-free production system
Beaudoin-Bussières et al. Elicitation of cluster A and Co-receptor binding site antibodies are required to eliminate HIV-1 infected cells
Tomar et al. Zika M—A potential viroporin: Mutational study and drug repurposing
Yang et al. A linear surface epitope in a proline-rich region of ORF3 product of genotype 1 hepatitis E virus