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Sintchak et al., 1996 - Google Patents

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

Sintchak et al., 1996

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Document ID
9611272906744474643
Author
Sintchak M
Fleming M
Futer O
Raybuck S
Chambers S
Caron P
Murcko M
Wilson K
Publication year
Publication venue
Cell

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Abstract The structure of inosine-5′-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and …
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    • C12N9/10—Transferases (2.)
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