Jovasevic et al., 2015 - Google Patents
GABAergic mechanisms regulated by miR-33 encode state-dependent fearJovasevic et al., 2015
View HTML- Document ID
- 936476614627881001
- Author
- Jovasevic V
- Corcoran K
- Leaderbrand K
- Yamawaki N
- Guedea A
- Chen H
- Shepherd G
- Radulovic J
- Publication year
- Publication venue
- Nature neuroscience
External Links
Snippet
Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand …
- 230000001419 dependent 0 title abstract description 61
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Jovasevic et al. | GABAergic mechanisms regulated by miR-33 encode state-dependent fear | |
Descalzi et al. | Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons | |
Liu et al. | Chromodomain Y-like protein–mediated histone crotonylation regulates stress-induced depressive behaviors | |
Wu et al. | Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP | |
Walker et al. | C9orf72 expansion disrupts ATM-mediated chromosomal break repair | |
Huang et al. | Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality | |
Aloisi et al. | Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice | |
Gao et al. | Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation | |
Mahajani et al. | Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors | |
Han et al. | A subpopulation of nociceptors specifically linked to itch | |
Agis‐Balboa et al. | A hippocampal insulin‐growth factor 2 pathway regulates the extinction of fear memories | |
Hou et al. | Correcting abnormalities in miR‐124/PTPN1 signaling rescues tau pathology in Alzheimer’s disease | |
Katsel et al. | Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia | |
Donegan et al. | Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner | |
Chun et al. | Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11. 2 microdeletion | |
Ribeiro et al. | Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine | |
Wan et al. | Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats | |
Wei et al. | Regulation of N-methyl-D-aspartate receptors by disrupted-in-schizophrenia-1 | |
McCullough et al. | Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction | |
Khlghatyan et al. | Mental illnesses-associated Fxr1 and its negative regulator Gsk3β are modulators of anxiety and glutamatergic neurotransmission | |
Khlghatyan et al. | Fxr1 regulates sleep and synaptic homeostasis | |
Werner et al. | Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence | |
Chen et al. | Leukemia inhibitory factor regulates Schwann cell proliferation and migration and affects peripheral nerve regeneration | |
Hoeffer et al. | Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation | |
Liu et al. | Mechanism of Snhg8/miR-384/Hoxa13/FAM3A axis regulating neuronal apoptosis in ischemic mice model |