Nothing Special   »   [go: up one dir, main page]

Varela et al., 1978 - Google Patents

Estrogen synthesis and estradiol binding by human mammary tumors

Varela et al., 1978

Document ID
8937836387473972545
Author
Varela R
Dao T
Publication year
Publication venue
Cancer Research

External Links

Snippet

Breast tumor homogenate from 17 patients was incubated with androstenedione, and 13 tumors yielded estrone and/or estradiol as metabolites. To ensure proper identification of the metabolites, we used a dual-labeling technique consisting of incubating tumor homogenate …
Continue reading at aacrjournals.org (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21

Similar Documents

Publication Publication Date Title
Varela et al. Estrogen synthesis and estradiol binding by human mammary tumors
Poortman et al. Androgen production and conversion to estrogens in normal postmenopausal women and in selected breast cancer patients
Fishman et al. Increased estrogen-16α-hydroxylase activity in women with breast and endometrial cancer
Fukushima et al. The characterization of four new metabolites of adrenocortical hormones
FRENCH et al. Testicular feminization: clinical, morphological and biochemical studies
Pion et al. Studies on the metabolism of C-21 steroids in the human foeto-placental unit
Van der Wall et al. Inhibition of the in vivo conversion of androstenedione to estrone by the aromatase inhibitor vorozole in healthy postmenopausal women
Dell'Acqua et al. STUDIES ON THE AROMATISATION OF NEUTRAL STEROIDS IN PREGNANT WOMEN: 6. Aromatisation of 16β-hydroxylated C-19 steroids by midterm placentas perfused in situ
NATHANSON et al. The effect of androgens on the urinary excretion of ketosteroids, nonketonic alcohols and estrogens
BONGIOVANNI et al. The urinary excretion of three C-21 methyl corticosteroids in the adrenogenital syndrome
West et al. Adrenal estrogens in patients with metastatic breast cancer
MacDonald et al. Regulation of extraadrenal steroid 21-hydroxylase activity: increased conversion of plasma progesterone to deoxycorticosterone during estrogen treatment of women pregnant with a dead fetus
SANDBERG et al. Androgen biosynthesis by ovarian lipoid cell tumor
Giannopoulos Uptake and metabolism of cortisone and cortisol by the fetal rabbit lung
Sulcová et al. 7-hydroxylation of dehydroepiandrosterone in human foetal liver, adrenals and chorion in vitro
SMITH et al. Studies on the Metabolism of Steroid Hormones and Their Precursors by the Human Placenta at Various Stages of Gestation. II. In Vitro Metabolism of 3β-Hydroxy androst-5-en-17-one
Jungmann et al. Biosynthesis and metabolism of neutral steroids by human midterm placenta and fetal liver
Kitchin III et al. Metabolism of progesterone by the term human placenta perfused in-situ
SOMMA et al. Site of origin of androgenic and estrogenic steroids in the normal human ovary
WARREN et al. Demonstration of 16α-hydroxylase in the human ovary
Jungmann et al. In vitro synthesis of estrogens by midterm human placenta and fetal liver
Mills et al. In vitro steroid synthesis by follicles isolated from the rabbit ovary
Dao Estrogen synthesis in human breast tumor and its inhibition by testololactone and bromoandrostenedione
Adams et al. Desmolase activity of normal and malignant human breast tissue
ENGEL et al. Clinical, morphological and biochemical studies on a malignant testicular tumor