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KOTANI et al., 2001 - Google Patents

Knockout of mouse β1, 4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane …

KOTANI et al., 2001

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Document ID
8813050744105305396
Author
KOTANI N
ASANO M
IWAKURA Y
TAKASAKI S
Publication year
Publication venue
Biochemical Journal

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Snippet

To understand the contribution of β1, 4-galactosyltransferase (β4Gal-T)-1 to galactosylation in vivo, N-glycans of hepatic membrane glycoproteins and plasma glycoproteins from β4Gal- T1 wild-type (β4Gal-T1+/+) and β4Gal-T1 knockout mice were compared. Unexpectedly …
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1081Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
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    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
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    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/18Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
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    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
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    • C12N9/14Hydrolases (3)
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    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12N9/2488Mannanases

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