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Magnus et al., 1987 - Google Patents

Stereospecific dicobalt octacarbonyl mediated enyne cyclization for the synthesis of the cytotoxic sesquiterpene (.+-.)-quadrone

Magnus et al., 1987

Document ID
873027484337547504
Author
Magnus P
Principe L
Slater M
Publication year
Publication venue
The Journal of Organic Chemistry

External Links

Snippet

Ethyl isobutyrate was converted into theenyne 20, through a straightforward sequence of transformations. Treatment of 20 with Co2 (CO) 8/CO/86 C, in the presence of 2, 6-di-ferf- butyl-4-methylpyridine (0.1 equiv), gave the bicyclo [3.3. 0] enone 25 (45%), in a completely …
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
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