Nothing Special   »   [go: up one dir, main page]

De Taeye et al., 2020 - Google Patents

FcγR binding and ADCC activity of human IgG allotypes

De Taeye et al., 2020

View HTML
Document ID
8631854707264597707
Author
De Taeye S
Bentlage A
Mebius M
Meesters J
Lissenberg-Thunnissen S
Falck D
Sénard T
Salehi N
Wuhrer M
Schuurman J
Labrijn A
Rispens T
Vidarsson G
Publication year
Publication venue
Frontiers in immunology

External Links

Snippet

Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and IgG3 through the IgG-Fc-receptor (FcγR) IIIa …
Continue reading at www.frontiersin.org (HTML) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses, e.g. hepatitis E virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Similar Documents

Publication Publication Date Title
De Taeye et al. FcγR binding and ADCC activity of human IgG allotypes
TWI734879B (en) Anti-ox40 antibodies and their uses
TWI718118B (en) Antibodies and chimeric antigen receptors specific for ror1
JP6840908B1 (en) IgG1 Fc mutant with effector function removed
Nesspor et al. Avidity confers FcγR binding and immune effector function to aglycosylated immunoglobulin G1
CN111601821B (en) Variants of Fc fragments having increased affinity for FcRn and increased affinity for at least one Fc fragment receptor
CA2627981A1 (en) Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof
CN111448314B (en) Selection of polypeptide drugs in eukaryotic cell display systems based on developability
CA2633080A1 (en) Method for preparing antibodies selective for activating fc receptors
JP7064666B2 (en) FcγRIIA-specific binding molecule and its use
CN110709417B (en) Human IgG with mutation 4 Is a polypeptide of (2)
CN107660212A (en) The monoclonal antibody of AntiCD3 McAb 03
JP2023507388A (en) Materials and methods for biological targeting in vivo
Chen et al. A general Fc engineering platform for the next generation of antibody therapeutics
US20240343811A1 (en) Cd16 antibody and use thereof
TW202043281A (en) Anti-cd38 binding domains
WO2022148413A1 (en) Antibody specifically binding to 4-1bb and antigen-binding fragment of antibody
CN114829407A (en) Screening for Fc γ R specific binding Fc Using mammalian display
WO2022233320A1 (en) Fc mutant with altered binding to fc receptor
US20230077531A1 (en) Fc VARIANT WITH ENHANCED AFFINITY TO Fc RECEPTORS AND IMPROVED THERMAL STABILITY
RU2820162C2 (en) VARIANTS WITH Fc-FRAGMENT, HAVING HIGH AFFINITY TO FcRn AND HIGH AFFINITY TO AT LEAST ONE RECEPTOR OF Fc-FRAGMENT
US20230059181A1 (en) IgE Antibody with Fcgamma Receptor binding
Jefferis Fc Protein Engineering
Chu Manipulating Human IgG3 Hinges as a Method of Studying the Structure and Function Relationship Between Hinge Length and Effector Function
CN116333102A (en) Hepatitis B antibodies with improved effector function