Nothing Special   »   [go: up one dir, main page]

Mathur et al., 2015 - Google Patents

Human iPSC-based cardiac microphysiological system for drug screening applications

Mathur et al., 2015

View HTML
Document ID
78843658355576510
Author
Mathur A
Loskill P
Shao K
Huebsch N
Hong S
Marcus S
Marks N
Mandegar M
Conklin B
Lee L
Healy K
Publication year
Publication venue
Scientific reports

External Links

Snippet

Drug discovery and development are hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy testing. A fundamental problem in this inefficient process is that non-human animal models cannot …
Continue reading at www.nature.com (HTML) (other versions)

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies

Similar Documents

Publication Publication Date Title
Mathur et al. Human iPSC-based cardiac microphysiological system for drug screening applications
Ronaldson-Bouchard et al. Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype
Abulaiti et al. Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
Low et al. Organs-on-chips: into the next decade
Sart et al. Multiscale cytometry and regulation of 3D cell cultures on a chip
Huebsch et al. Miniaturized iPS-cell-derived cardiac muscles for physiologically relevant drug response analyses
Kimlin et al. 3D in vitro tissue models and their potential for drug screening
Horvath et al. Screening out irrelevant cell-based models of disease
Thavandiran et al. Functional arrays of human pluripotent stem cell-derived cardiac microtissues
Benien et al. 3D tumor models: history, advances and future perspectives
Gracz et al. A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis
Pioner et al. Optical investigation of action potential and calcium handling maturation of hiPSC-cardiomyocytes on biomimetic substrates
Kreutzer et al. Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes
Huang et al. Centrifugation-assisted single-cell trapping in a truncated cone-shaped microwell array chip for the real-time observation of cellular apoptosis
Sheehy et al. Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes
Feinberg et al. Functional differences in engineered myocardium from embryonic stem cell-derived versus neonatal cardiomyocytes
Bürgel et al. Automated, multiplexed electrical impedance spectroscopy platform for continuous monitoring of microtissue spheroids
Dettinger et al. Automated microfluidic system for dynamic stimulation and tracking of single cells
Poli et al. Experimental and computational methods for the study of cerebral organoids: a review
Visone et al. Enhancing all-in-one bioreactors by combining interstitial perfusion, electrical stimulation, on-line monitoring and testing within a single chamber for cardiac constructs
Cooksey et al. Reproducibility and robustness of a real-time microfluidic cell toxicity assay
Bertulli et al. Image-assisted microvessel-on-a-chip platform for studying cancer cell transendothelial migration dynamics
Tamargo et al. milliPillar: a platform for the generation and real-time assessment of human engineered cardiac tissues
Agrawal et al. Devices and techniques used to obtain and analyze three‐dimensional cell cultures
Ribeiro et al. A new versatile platform for assessment of improved cardiac performance in human-engineered heart tissues