Naumer et al., 2012 - Google Patents
Development and validation of novel AAV2 random libraries displaying peptides of diverse lengths and at diverse capsid positionsNaumer et al., 2012
- Document ID
- 762131757391949900
- Author
- Naumer M
- Ying Y
- Michelfelder S
- Reuter A
- Trepel M
- Müller O
- Kleinschmidt J
- Publication year
- Publication venue
- Human gene therapy
External Links
Snippet
Libraries based on the insertion of random peptide ligands into the capsid of adeno- associated virus type 2 (AAV2) have been widely used to improve the efficiency and selectivity of the AAV vector system. However, so far only libraries of 7-mer peptide ligands …
- 210000000234 Capsid 0 title abstract description 109
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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