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Drake et al., 2022 - Google Patents

Asthmatic Lung Fibroblasts Produce Increased Levels of TSLP Upon TNFa Stimulation via the ER Stress Response Pathway

Drake et al., 2022

Document ID
7493737860688633837
Author
Drake L
Roos B
Pabelick C
Prakash Y
Publication year
Publication venue
B63. FROM AIRWAYS TO ALVEOLI: MECHANISTIC AND CLINICAL STUDIES

External Links

Snippet

RATIONALE: Thymic stromal lymphopoietin (TSLP) plays an important role in asthma pathogenesis. Lung fibroblasts are an important cellular source of TSLP production under inflammatory conditions. However, it is unknown whether human asthmatic fibroblasts …
Continue reading at www.atsjournals.org (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone

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Drake et al. Asthmatic Lung Fibroblasts Produce Increased Levels of TSLP Upon TNFa Stimulation via the ER Stress Response Pathway
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