Nothing Special   »   [go: up one dir, main page]

Kumai et al., 2000 - Google Patents

Loss of connexin45 causes a cushion defect in early cardiogenesis

Kumai et al., 2000

View PDF
Document ID
6979803811313707305
Author
Kumai M
Nishii K
Nakamura K
Takeda N
Suzuki M
Shibata Y
Publication year
Publication venue
Development

External Links

Snippet

At around embryonic day 9, the primitive heart of a mouse embryo undergoes spectacular alterations within 24 hours. We created mice harboring an nls-lacZ gene in place of connexin45, which encodes the only known gap junction protein in the primitive heart before …
Continue reading at www.researchgate.net (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Similar Documents

Publication Publication Date Title
Kumai et al. Loss of connexin45 causes a cushion defect in early cardiogenesis
Zhou et al. Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA‐2 in urogenital development
Krüger et al. Defective vascular development in connexin 45-deficient mice
Tallquist et al. Cell autonomous requirement for PDGFRα in populations of cranial and cardiac neural crest cells
Parlakian et al. Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality
Thépot et al. Targeted disruption of the murine jun D gene results in multiple defects in male reproductive function
Coffinier et al. Essential role for the homeoprotein vHNF1/HNF1β in visceral endoderm differentiation
Feiner et al. Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption
Xin et al. Smooth muscle expression of Cre recombinase and eGFP in transgenic mice
Grier et al. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4
Barbacci et al. Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification
Jeays-Ward et al. Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad
Cheng et al. Tissue-specific ablation of the LIF receptor in the murine uterine epithelium results in implantation failure
Boulday et al. Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations
Rucker III et al. Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis
Walz et al. Aberrant sensory innervation of the olfactory bulb in neuropilin-2 mutant mice
Gogos et al. Genetic ablation and restoration of the olfactory topographic map
Kuraguchi et al. Adenomatous polyposis coli (APC) is required for normal development of skin and thymus
Brewer et al. Wnt1-Cre-mediated deletion of AP-2α causes multiple neural crest-related defects
Weiler-Guettler et al. Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos
Reichelt et al. Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice
Pirity et al. Rybp/DEDAF is required for early postimplantation and for central nervous system development
Rodriguez et al. Cited1 is required in trophoblasts for placental development and for embryo growth and survival
Pazirandeh et al. Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene
Puech et al. Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region