Lind et al., 1995 - Google Patents
Novel forms of B‐domain‐deleted recombinant factor VIII molecules: construction and biochemical characterizationLind et al., 1995
View PDF- Document ID
- 651519490575382947
- Author
- Lind P
- Larsson K
- Spira J
- Sydow‐Báckman M
- Almstedt A
- Gray E
- Sandberg H
- Publication year
- Publication venue
- European Journal of Biochemistry
External Links
Snippet
Recombinant molecules similar to the smallest active plasma‐derived factor VIII molecule, a complex of an 80‐kDa and a 90‐kDa polypeptide chain lacking the B domain, have been produced using various factor VIII cDNA constructs in order to obtain primary translation …
- 108010025139 recombinant factor VIII SQ 0 title abstract description 37
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lind et al. | Novel forms of B‐domain‐deleted recombinant factor VIII molecules: construction and biochemical characterization | |
| EP2591101B1 (en) | Systems for factor viii processing and methods thereof | |
| EP0506757B1 (en) | A recombinant human factor viii derivative | |
| Pittman et al. | Role of the B domain for factor VIII and factor V expression and function | |
| AU643247B2 (en) | Activatable fibrinolytic and anti-thrombotic proteins | |
| EP0533862B1 (en) | Recombinant human factor viii derivatives | |
| US7220849B2 (en) | Enhanced gamma-carboxylation of recombinant vitamin K-dependent clotting factor | |
| JP2771129B2 (en) | Protein complex having factor VIII: C activity and method for producing the same | |
| CZ20031718A3 (en) | Von Willebrand factor (vWF) splitting polypeptide protease, nucleic acid encoding the polypeptide and use of such polypeptide | |
| JPH09512710A (en) | Recombinant fibrin chain, fibrin and fibrin-homolog | |
| US6958322B1 (en) | Factor X analog with an improved ability to be activated | |
| JP2872255B2 (en) | High yield production method of factor VIII | |
| CA2411694C (en) | Furin polypeptides with improved characteristics | |
| EP1444986A1 (en) | Pharmaceutical preparation for the improved treatment of blood-clotting disorders | |
| US5869292A (en) | Hybrid proteins with modified activity | |
| US11708570B2 (en) | Compositions and methods for modulating Factor IX function | |
| Standker et al. | In vivo degradation of human fibrinogen Aα: detection of cleavage sites and release of antithrombotic peptides | |
| Malm et al. | Expression of completely γ‐carboxylated and β‐hydroxylated recombinant human vitamin‐K‐dependent protein S with full biological activity | |
| Norman et al. | Stable expression, secretion, and characterization of active human renin in mammalian cells. | |
| Przysiecki et al. | Characterization of recombinant antistasin secreted by Saccharomyces cerevisiae | |
| Guarna et al. | Factor X Fusion Proteins: Improved Production and Use in the Release in Vitro of Biologically Active Hirudin from an Inactive α-Factor–Hirudin Fusion Protein | |
| US20230250412A1 (en) | Compositions and Methods for Modulating Factor IX Function | |
| JPH0564588A (en) | Human protein c having short heavy chain and activated human protein c | |
| EP1454632A1 (en) | Pharmaceutical preparation for the treatment of blood-clotting disorders containing factor VIII derived peptides | |
| ZA200304741B (en) | Von willebrand factor (vWF) cleaving protease polypeptide, nucleic acid encoding the polypeptide and use of polypeptide. |