Liu et al., 2017 - Google Patents
Topology engineering of proteins in vivo using genetically encoded, mechanically interlocking SpyX modules for enhanced stabilityLiu et al., 2017
View PDF- Document ID
- 6453230380018639825
- Author
- Liu D
- Wu W
- Liu Y
- Wu X
- Cao Y
- Song B
- Li X
- Zhang W
- Publication year
- Publication venue
- ACS Central Science
External Links
Snippet
Recombinant proteins are traditionally limited to linear configuration. Herein, we report in vivo protein topology engineering using highly efficient, mechanically interlocking SpyX modules named AXB and BXA. SpyX modules are protein domains composed of p53dim …
- 102000004169 proteins and genes 0 title abstract description 425
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
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