Nothing Special   »   [go: up one dir, main page]

Ebenhan et al., 2014 - Google Patents

Peptide synthesis, characterization and 68Ga-radiolabeling of NOTA-conjugated ubiquicidin fragments for prospective infection imaging with PET/CT

Ebenhan et al., 2014

View PDF
Document ID
5345256759537294205
Author
Ebenhan T
Chadwick N
Sathekge M
Govender P
Govender T
Kruger H
Marjanovic-Painter B
Zeevaart J
Publication year
Publication venue
Nuclear medicine and biology

External Links

Snippet

Introduction Human antimicrobial peptides are of interest for the development of positron emission tomography (PET) tracers as they exhibit desirable characteristics that make them good candidates for targeting vectors. Due to their natural role in the innate immune system …
Continue reading at www.researchgate.net (PDF) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
    • A61K47/48—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Similar Documents

Publication Publication Date Title
Ebenhan et al. Peptide synthesis, characterization and 68Ga-radiolabeling of NOTA-conjugated ubiquicidin fragments for prospective infection imaging with PET/CT
EP3470418B1 (en) Site-specific radioisotope-labeled antibody using igg-binding peptide
Miao et al. In vivo evaluation of 188Re‐labeled alpha‐melanocyte stimulating hormone peptide analogs for melanoma therapy
Sutcliffe-Goulden et al. Rapid solid phase synthesis and biodistribution of 18 F-labelled linear peptides
Mokaleng et al. Synthesis, 68Ga‐Radiolabeling, and Preliminary In Vivo Assessment of a Depsipeptide‐Derived Compound as a Potential PET/CT Infection Imaging Agent
Guo et al. Cu-64-labeled lactam bridge-cyclized α-MSH peptides for PET imaging of melanoma
KR20040068363A (en) Labeling Targeting Agents with Gallium-68 and Gallium-67
Meléndez-Alafort et al. Lys and Arg in UBI: a specific site for a stable Tc-99m complex?
Kapty et al. Radiolabeling of phosphatidylserine-binding peptides with prosthetic groups N-[6-(4-[18F] fluorobenzylidene) aminooxyhexyl] maleimide ([18F] FBAM) and N-succinimidyl-4-[18F] fluorobenzoate ([18F] SFB)
Dutta et al. Synthesis, in vitro evaluation, and 68Ga‐radiolabeling of CDP 1 toward PET/CT imaging of bacterial infection
CN114585393A (en) RI-labeled humanized antibodies
Miao et al. Reducing renal uptake of 90Y-and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues
Yang et al. Synthesis and evaluation of 68Ga-labeled DOTA-2-deoxy-D-glucosamine as a potential radiotracer in μPET imaging
Bhatt et al. Gallium-68 labeled Ubiquicidin derived octapeptide as a potential infection imaging agent
Yang et al. Formulation of 68Ga BAPEN kit for myocardial positron emission tomography imaging and biodistribution study
Nielsen et al. 68Ga-labeled phage-display selected peptides as tracers for positron emission tomography imaging of Staphylococcus aureus biofilm-associated infections: Selection, radiolabelling and preliminary biological evaluation
Kim et al. Synthesis and evaluation of novel Tc‐99 m labeled NGR‐containing hexapeptides as tumor imaging agents
Dos Santos et al. Scintigraphic imaging of Staphylococcus aureus infection using 99mTc radiolabeled aptamers
Oh et al. Direct Fluorination Strategy for the Synthesis of Fluorine‐18 Labeled Oligopeptide—[18F] ApoPep‐7
Mdlophane et al. Comparison of DOTA and NODAGA as chelates for 68 Ga-labelled CDP1 as novel infection PET imaging agents
Chopra et al. Radiosynthesis and pre-clinical evaluation of [68Ga] labeled antimicrobial peptide fragment GF-17 as a potential infection imaging PET radiotracer
Naqvi et al. Radiosynthesis and preclinical studies of 177 Lu-labeled sulfadiazine: a possible theranostic agent for deep-seated bacterial infection
Satpati et al. Synthesis of [64 Cu] DOTA-ADIBON 3-Ala-PEG 28-A20FMDV2 via copper-free click chemistry for PET imaging of integrin α v β 6
Mushtaq et al. Radiolabeling and preliminary biodistribution study of 99mTc-labeled antibody-mimetic scaffold protein repebody for initial clearance properties
Dijkgraaf et al. Strategies for Site-Specific Radiolabeling of Peptides and Proteins