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Ludlow et al., 2018 - Google Patents

NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer

Ludlow et al., 2018

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Document ID
4676517909879562076
Author
Ludlow A
Wong M
Robin J
Batten K
Yuan L
Lai T
Dahlson N
Zhang L
Mender I
Tedone E
Sayed M
Wright W
Shay J
Publication year
Publication venue
Nature communications

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Snippet

Alternative splicing is dysregulated in cancer and the reactivation of telomerase involves the splicing of TERT transcripts to produce full-length (FL) TERT. Knowledge about the splicing factors that enhance or silence FL hTERT is lacking. We identified splicing factors that …
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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