Nothing Special   »   [go: up one dir, main page]

Hofmann et al., 2002 - Google Patents

Recent advances in the application of expressed protein ligation to protein engineering

Hofmann et al., 2002

Document ID
4447231256833636374
Author
Hofmann R
Muir T
Publication year
Publication venue
Current opinion in biotechnology

External Links

Snippet

Expressed protein ligation is a technique for joining recombinantly expressed proteins to polypeptides containing biophysical probes, post-translational modifications or unnatural amino acids. Recent advances have expanded the scope of expressed protein ligation and …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids

Similar Documents

Publication Publication Date Title
Hofmann et al. Recent advances in the application of expressed protein ligation to protein engineering
Nilsson et al. Chemical synthesis of proteins
Reguera et al. Multicomponent reaction toolbox for peptide macrocyclization and stapling
Hackenberger et al. Chemoselective ligation and modification strategies for peptides and proteins
Cotton et al. Peptide ligation and its application to protein engineering
Burke et al. Exploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology
Nuijens et al. Natural occurring and engineered enzymes for peptide ligation and cyclization
Tsukiji et al. Sortase‐mediated ligation: a gift from gram‐positive bacteria to protein engineering
Muralidharan et al. Protein ligation: an enabling technology for the biophysical analysis of proteins
McGrath et al. Chemoselectivity in chemical biology: acyl transfer reactions with sulfur and selenium
Berrade et al. Expressed protein ligation: a resourceful tool to study protein structure and function
Kent Chemical protein synthesis: Inventing synthetic methods to decipher how proteins work
Peacock et al. Discovery of de novo macrocyclic peptides by messenger RNA display
Durek et al. Protein semi-synthesis: new proteins for functional and structural studies
Panda et al. Traceless chemical ligation from S-, O-, and N-acyl isopeptides
Shelton et al. A facile N-mercaptoethoxyglycinamide (MEGA) linker approach to peptide thioesterification and cyclization
Arbour et al. Bringing macrolactamization full circle: self-cleaving head-to-tail macrocyclization of unprotected peptides via mild N-acyl urea activation
Harmand et al. New chemistries for chemoselective peptide ligations and the total synthesis of proteins
Zuo et al. Chemical synthesis and biophysical applications of membrane proteins
Wills et al. Site‐Selective Peptide Macrocyclization
Sakamoto et al. Synthetic procedure for N-Fmoc amino acyl-N-sulfanylethylaniline linker as crypto-peptide thioester precursor with application to native chemical ligation
Bouchenna et al. The role of the conserved SUMO-2/3 cysteine residue on domain structure investigated using protein chemical synthesis
Dao et al. α-Selective lysine ligation and application in chemical synthesis of interferon gamma
Chen et al. Native Peptide Cyclization, Sequential Chemoselective Amidation in Water
Agouridas et al. Redox-controlled chemical protein synthesis: sundry shades of latency