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Makino et al., 2013 - Google Patents

The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma

Makino et al., 2013

Document ID
4409544855100513241
Author
Makino K
Jinnin M
Hirano A
Yamane K
Eto M
Kusano T
Honda N
Kajihara I
Makino T
Sakai K
Masuguchi S
Fukushima S
Ihn H
Publication year
Publication venue
The Journal of Immunology

External Links

Snippet

Systemic and localized scleroderma (SSc and LSc) is characterized by excessive deposition of collagen and tissue fibrosis in the skin. Although they have fundamental common characteristics including autoimmunity, little is known about the exact mechanism that …
Continue reading at journals.aai.org (other versions)

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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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