Makino et al., 2013 - Google Patents
The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized sclerodermaMakino et al., 2013
- Document ID
- 4409544855100513241
- Author
- Makino K
- Jinnin M
- Hirano A
- Yamane K
- Eto M
- Kusano T
- Honda N
- Kajihara I
- Makino T
- Sakai K
- Masuguchi S
- Fukushima S
- Ihn H
- Publication year
- Publication venue
- The Journal of Immunology
External Links
Snippet
Systemic and localized scleroderma (SSc and LSc) is characterized by excessive deposition of collagen and tissue fibrosis in the skin. Although they have fundamental common characteristics including autoimmunity, little is known about the exact mechanism that …
- 229920001239 microRNA 0 title abstract description 120
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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