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Article
Piperazine-derived ionizable lipids for enhanced mRNA delivery and cancer immunotherapy
Messenger ribonucleic acid (mRNA)-based therapeutics hold great prospects in disease treatment and lipid nanoparticles (LNPs) are the most extensively applied non-viral platform for RNA delivery in clinics. De...
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Article
Open AccessBlocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells
Acute pancreatitis (AP) continues to pose a major challenge as targeted therapeutic interventions are absent. Mitochondrial dysfunction and inflammasome-dependent pyroptosis are involved in the pathogenic mech...
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Article
Antagonistic activity of selenium-enriched Bifidobacterium breve against Clostridioides difficile
Probiotics have the potential to be used in the prevention of Clostridioides difficile infection (CDI). In this study, selenium (Se)-enriched Bifidobacterium breve YH68-Se was obtained under optimal culture condi...
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Article
mTOR inhibitor PP242 increases antitumor activity of sulforaphane by blocking Akt/mTOR pathway in esophageal squamous cell carcinoma
Sulforaphane (SFN) is a kind of isothiocyanate from cruciferous vegetables with extensive anti-tumor activity. Esophageal squamous cell carcinoma (ESCC) is a popular malignancy in East Asia, East and South Afr...
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Chapter
Segment-Long-Spacing (SLS) and the Polymorphic Structures of Fibrillar Collagen
The diverse and complex functions of collagen during the development of an organism are closely related to the polymorphism of its supramolecular structures in the extracellular matrix. SLS (segment-long-spaci...
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Article
Open AccessInhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis
The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance. Inhibition of the Otub1/c-Maf axis is a promising therape...
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Article
Open AccessAnti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf
As a deubiqutinase Otub1 stabilizes and promotes the oncogenic activity of the transcription factor c-Maf in multiple myeloma (MM), a malignancy of plasma cells. In the screen for bioactive inhibitors of the O...
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Article
Analyses on the binding interaction between rice glutelin and conjugated linoleic acid by multi-spectroscopy and computational docking simulation
It is an interesting topic to elucidate the interaction among plant proteins and bioactive lipid components. However, there is a shortage of understanding regarding the nature of the interaction between rice p...
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Article
Feasibility assessment of up-flow anaerobic sludge blanket treatment of sulfamethoxazole pharmaceutical wastewater
Treatment of sulfamethoxazole pharmaceutical wastewater is a big challenge. In this study, a series of anaerobic evaluation tests on pharmaceutical wastewater from different operating units was conducted to ev...
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Article
Open AccessInhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis
The deubiquitinase USP5 stabilizes c-Maf, a key transcription factor in multiple myeloma (MM), but the mechanisms and significance are unclear. In the present study, USP5 was found to interact with c-Maf and p...
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Article
Open AccessThe ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis
UBE2O is proposed as a ubiquitin-conjugating enzyme, but its function was largely unknown.
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Article
Evidence for an unfolding and refolding pathway in cytochrome c
It has been suggested that three partially unfolded forms detected in a native state hydrogen exchange study of oxidized cytochrome c may represent sequential in...
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