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Open AccessA protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to emerge and evade immunity, resulting in breakthrough infections in vaccinated populations. There is an urgent need for the d...
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Open AccessGenome-wide DNA methylation profiling reveals a novel hypermethylated biomarker PRKCB in gastric cancer
Globally, gastric cancer (GC) ranks among the most prevalent forms of malignancy, posing a significant health burden. Epigenetic modifications, predominantly characterized by alterations in DNA methylation pat...
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Suicidal ideation in Chinese patients with chronic schizophrenia: prevalence, clinical correlates, and relationship with alexithymia
Suicidal ideation (SI) is common among people with schizophrenia. However, it has received less attention than suicide attempts (SA), especially in the Chinese population. Alexithymia is a well-established ris...
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Employing Bayesian analysis to establish a cut-off point and assess stigma prevalence in substance use disorder: a comprehensive study of the Chinese version of the Substance Use Stigma Mechanism Scale
In China, individuals with substance use disorders (SUD) face severe stigma, but reliable stigma assessment tool is lacking. Therefore, this study aimed to validate the Chinese version of the Substance Use Sti...
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Open AccessNondestructive detection of saline-alkali stress in wheat (Triticum aestivum L.) seedlings via fusion technology
Wheat (Triticum aestivum L.) is an important grain crops in the world, and its growth and development in different stages is seriously affected by saline-alkali stress, especially in seedling stage. Therefore, no...
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Metal and ligand modification modulates the electrocatalytic HER, OER, and ORR activity of 2D conductive metal-organic frameworks
It is highly desirable to design efficient and stable hydrogen evolution reaction (HER) and oxygen evolution/reduction reaction (OER/ORR) electrocatalysts for the development of renewable energy technologies. ...
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Open AccessCHIKV infection drives shifts in the gastrointestinal microbiome and metabolites in rhesus monkeys
Many studies have demonstrated the association between intestinal microbiota and joint diseases. The “gut-joint axis” also has potential roles in chikungunya virus (CHIKV) infection. Pro-inflammatory arthritis...
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Open AccessIn-situ atomic tracking of intermetallic compound formation during thermal annealing
Intermetallic compounds (IMCs) with ordered atomic structure have gained great attention as nanocatalysts for its enhanced activity and stability. Although the reliance of IMC preparation on high-temperature a...
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Open AccessThe inoculum dose of Zika virus can affect the viral replication dynamics, cytokine responses and survival rate in immunocompromised AG129 mice
Zika virus, a mosquito-borne arbovirus, has repeatedly caused large pandemics with symptoms worsening from mild and self-limiting diseases to Guillain–Barré syndrome in adults and fetal microcephaly in newborn...
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Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study
Emerging studies indicate that oxidative stress may contribute to deficit syndrome (DS) in patients with schizophrenia. Homocysteine (Hcy) is a well-known marker and mediator of oxidative stress that exhibits ...
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A Janus dual-atom catalyst for electrocatalytic oxygen reduction and evolution
Dual-atom catalysts, which exhibit high activity and atom utilization, show promise for sustainable energy conversion and storage technologies. However, the rational design and synthesis of a dual-atom catalys...
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Association between sleep problems and impulsivity mediated through regional homogeneity abnormalities in male methamphetamine abstainers
Sleep problems and impulsivity frequently occur in methamphetamine (MA) abstainers and are linked to aberrant brain function. However, the interplay between these factors remains poorly understood. This study ...
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Optimization of the Procedure for Gram Scale Synthesis of Silicon Rhodamine and its Application in Labeling BRD4 Kinase Inhibitor
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Open AccessPurines enrich root-associated Pseudomonas and improve wild soybean growth under salt stress
The root-associated microbiota plays an important role in the response to environmental stress. However, the underlying mechanisms controlling the interaction between salt-stressed plants and microbiota are po...
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Association of subclinical hypothyroidism with metabolic syndrome and its components among outpatients with first-episode drug-naïve major depressive disorder: a large-scale cross-sectional study
Both metabolic syndrome (MetS) and subclinical hypothyroidism (SCH) are prevalent in major depressive disorder (MDD) patients. However, their relationship in this population remains unknown. The study assessed...
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The effect of vibration frequency on shear punch strength and wear resistance of AZ70 magnesium matrix composite manufactured by FSVP
A friction stir vibration processing (FSVP) with different vibration frequencies (20 Hz, 40 Hz, and 80 Hz) was employed for the fabrication of AZ70/ZrO2–CeO2 surface composite with the aim of improving mechanical...
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Article
Hydrogeochemical signatures origin of a karst geothermal reservoir–the Sinian Dengying Formation in northern Guizhou, China
The karst geothermal reservoir, Sinian Dengying Formation was investigated from the hydrogeochemical perspective. Integrated techniques including XRD + SEM, isotopes, saturation index and PHREEQC modeling were...
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Article
Climate and Environmental Variables Drive Stream Biofilm Bacterial and Fungal Diversity on Tropical Mountainsides
High mountain freshwater systems are particularly sensitive to the impacts of global warming and relevant environmental changes. Microorganisms contribute substantially to biogeochemical processes, yet their d...
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Relationships Between Impulsivity, Methamphetamine use Disorder and Gambling Disorder
Methamphetamine use disorder (MAUD) and gambling disorder (GD) frequently co-occur. Individuals with both conditions are typically more difficult to treat than those with either disorder alone. This study aime...
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Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model
Several studies have identified the effects of methamphetamine (MA) on central dopaminergic neurons, but its effects on enteric dopaminergic neurons (EDNs) are unclear. The aim of this study was to investigate...
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