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Distinct effects of dilute acid prehydrolysate inhibitors on enzymatic hydrolysis and yeast fermentation
The effects of dilute acid prehydrolysate from poplar were investigated and compared in the enzymatic hydrolysis, fermentation, and simultaneous saccharification fermentation (SSF) in this study. The improveme...
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Article
Open AccessDevelopment of a nomogram-based model incorporating radiomic features from follow-up longitudinal lung CT images to distinguish invasive adenocarcinoma from benign lesions: a retrospective study
To develop and validate a radiomic model for differentiating pulmonary invasive adenocarcinomas from benign lesions based on follow-up longitudinal CT images.
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Open AccessS-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis
Radiation-induced lung injury (RILI) is associated with alveolar epithelial cell death and secondary fibrosis in injured lung. Mesenchymal stem cell (MSC)-derived exosomes have regenerative effect against lung...
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Open AccessPhysiological, biochemical, and transcriptomic alterations in Castor (Ricinus communis L.) under polyethylene glycol-induced oxidative stress
Castor is an important industrial raw material. Drought-induced oxidative stress leads to slow growth and decreased yields in castor. However, the mechanisms of drought-induced oxidative stress in castor remai...
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Open AccessThe short-term outcomes and risk factors of post-myocardial infarction ventricular septal rupture: a multi-center retrospective Study
Post-myocardial infarction ventricular septal rupture (PIVSR) is one of the most severe types of mechanical complications after acute myocardial infarction (AMI) with high mortality and poor prognosis. The ris...
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Open AccessThe association of early pregnancy dyslipidemia with preterm birth in twin pregnancies: a retrospective cohort study
Maternal lipid metabolism has been implicated in elevating the risk of adverse pregnancy outcomes, which is a particularly significant concern in twin pregnancies. However, the precise relationship between ear...
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Article
Open AccessEffects of tillage management on soil organic carbon mineralization under double cropping rice system of southern China
Soil organic carbon (SOC) plays a vital role in maintaining or enhancing soil fertility and quality of paddy field, but there is still limited information about how SOC mineralization responds to different til...
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Article
Open AccessModeling the co-circulation of influenza and COVID-19 in Hong Kong, China
After abandoning the zero-case strategy for COVID-19 in December 2022 in mainland China, the Hong Kong Special Administrative Region of China (HKSAR) has undergone an anticipated surge of the prevalence of COV...
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Article
Open AccessThe association between child maltreatment, cognitive reappraisal, negative coping styles, and non-suicidal self-injury in adolescents with major depressive disorder
Non-suicidal self-injury (NSSI) is a significant public health concern among adolescents with major depressive disorders (MDD). Although previous research has linked child maltreatment (CM) to NSSI, the precis...
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Article
The Brønsted-Lewis Acid Sites in Metal–Organic Framework Biomimetic Nanozyme for Cooperatively Enhancing the Hydrolysis of Lactose
In order to solve the problem of the low efficiency of lactose hydrolysis using traditional metal–organic frameworks (MOFs) nanozymes, Brønsted acid active sites (-COOH) were firstly introduced into Fe-MIL-101...
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Article
Open AccessEstablishment of a nomogram to predict the overall survival of patients with collecting duct renal cell carcinoma
Collecting duct carcinoma (CDC) is a rare histological type of renal cell carcinoma that lacks a prognostic prediction model. In this study, we developed a nomogram to predict the prognosis of CDC patients.
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Open AccessLiver-specific delivery of spherical DNA frameworks for alleviation of hepatic ischemic reperfusion injury
DNA nanostructures have long been developed for biomedical purposes, but their controlled delivery in vivo proposes a major challenge for disease theranostics. We previously reported that DNA nanostructures on...
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Article
Histidine modified Fe3O4 nanoparticles improving the ethanol yield and tolerance of Saccharomyces cerevisiae
Saccharomyces cerevisiae, the primary microorganism involved in ethanol production, is hindered by the accumulation of ethanol, leading to reduced ethanol production. In this study, we employed histidine-modified...
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Article
Open AccessTlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Toll-like receptor 9 (TLR9) recognizes bacterial, viral and self DNA and play an important role in immunity and inflammation. However, the role of TLR9 in obesity is less well-studied. Here, we generate B-cell...
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Development of alkaline phosphatase-linked single-chain variable fragment fusion proteins for one-step immunodetection of deoxynivalenol in cereals
Deoxynivalenol (DON) is a mycotoxin that widely distributes in various foods and seriously threatens food safety. To minimize the consumers’ dietary exposure to DON, there is an urgent demand for developing ra...
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Article
Open AccessMaternal vitamin D status and risk of gestational diabetes mellitus in twin pregnancies: a longitudinal twin pregnancies birth cohort study
Gestational diabetes mellitus (GDM) is a common complication of pregnancy, with significant short-term and long-term implications for both mothers and their offspring. Previous studies have indicated the poten...
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Article
Fibroblast subtypes in pancreatic cancer and pancreatitis: from mechanisms to therapeutic strategies
Excessive fibrosis is a predominant feature of pancreatic stroma and plays a crucial role in the development and progression of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Emerging e...
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Open AccessA deep-learning-based framework for identifying and localizing multiple abnormalities and assessing cardiomegaly in chest X-ray
Accurate identification and localization of multiple abnormalities are crucial steps in the interpretation of chest X-rays (CXRs); however, the lack of a large CXR dataset with bounding boxes severely constrai...
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Article
Open AccessKARR-seq reveals cellular higher-order RNA structures and RNA–RNA interactions
RNA fate and function are affected by their structures and interactomes. However, how RNA and RNA-binding proteins (RBPs) assemble into higher-order structures and how RNA molecules may interact with each othe...
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Pros and Cons in Various Immobilization Techniques and Carriers for Enzymes
In recent years, enzyme immobilization technology has been developed, and studies on immobilized enzyme materials have become very prominent. With the immobilization technique, enzymes and compatible carrier m...
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