Papers by PRADEEP PATERIYA
International Journal of Indigenous Herbs and Drugs, Apr 30, 2018
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Journal of Basic and Clinical Physiology and Pharmacology, 2020
Background Inflammation is the most common health problem faced in life relating to a vast number... more Background Inflammation is the most common health problem faced in life relating to a vast number of diseases. The present study evaluated the pharmacological effect of three plants (Vitex thyrsiflora, Entandrophragma cylindricum, and Anonidium mannii) commonly used in the Cameroon pharmacopeia for the management of inflammatory response. Methods The pharmacological effect was characterized by the antioxidant capacity, anti-inflammatory, analgesic, and antipyretic properties of the ethanol extracts of the three plants. Antioxidant capacity was determined using total phenolic content, total flavonoid content, hydrogen peroxide, ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) radical scavenging assays. Anti-inflammatory activity was evaluated in vitro by protein denaturation and hypotonic-induced hemolysis methods and in vivo by carrageenan paw edema method. Analgesic and antipyretic activitie...
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Aims: This study was designed to elucidate the antioxidant, analgesic and antipyretic activities ... more Aims: This study was designed to elucidate the antioxidant, analgesic and antipyretic activities of the ethanol extract of the stem bark of Dichaetanthera africana. Place and Duration of Study: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, India, between September 2014 and November 2014.
Methodology: Antioxidant activities were determined in vitro by the total phenolic, total flavonoid, ferric reducing antioxidant power (FRAP), DPPH, hydrogen peroxide and ABTS methods. Analgesic and antipyretic activities were investigated using the acetic acid induced writhing and brewer’s yeast induced hyperpyrexia assays respectively.
Results: Ethanol extract had high phenolic (4.15-44.35 mgCA/g) and flavonoid (85.56-596.7 mgCA/g) contents and FRAP (187.87-371.41 mgCA/g). This extract exhibited strong DPPH (IC50 = 0.49 μg/ml), H2O2 (IC50 = 1.62 μg/ml) and ABTS (IC50= 0.43 μg/ml) radical scavenging activities. Significant reduction of abdominal writhing (P<0.001) and fever (P< 0.001) were observed in rats in a dose dependent manner after administration of the ethanol extract with the most effective dose being 400 mg/kg b.w.
Conclusion: These results provide promising baseline information
for the potential use of Dichaetanthera africana in the treatment of pain and fever.
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Aims: This study was designed to elucidate the antioxidant, analgesic and antipyretic activities ... more Aims: This study was designed to elucidate the antioxidant, analgesic and antipyretic activities of the ethanol extract of the stem bark of Dichaetanthera africana. Place and Duration of Study: Methodology: Antioxidant activities were determined in vitro by the total phenolic, total flavonoid, ferric reducing antioxidant power (FRAP), DPPH, hydrogen peroxide and ABTS methods. Analgesic and antipyretic activities were investigated using the acetic acid induced writhing and brewer's yeast induced hyperpyrexia assays respectively. Results: Ethanol extract had high phenolic (4.15-44.35 mgCA/g) and flavonoid (85.56-596.7 mgCA/g) contents and FRAP (187.87-371.41 mgCA/g). This extract exhibited strong DPPH (IC 50 = 0.49 µg/ml), H 2 O 2 (IC 50 = 1.62 µg/ml) and ABTS (IC 50 = 0.43 µg/ml) radical scavenging activities. Significant reduction of abdominal writhing (P< 0.001) and fever (P< 0.001) were observed in rats in a dose dependent manner after administration of the ethanol extract with the most effective dose being 400 mg/kg b.w. Conclusion: These results provide promising baseline information for the potential use of Dichaetanthera africana in the treatment of pain and fever.
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All living organisms utilize oxygen to metabolize and use the dietary nutrients in order to produ... more All living organisms utilize oxygen to metabolize and use the dietary nutrients in order to produce energy for survival. Oxygen thus is a vital component for living. Oxygen meditates chemical reactions that metabolize fats, proteins, and carbohydrates to produce energy. While oxygen is one of the most essential components for living, it is also a double edged sword. Oxygen is a highly reactive atom that is capable of becoming part of potentially damaging molecules commonly called free radicals. These free radicals are capable of attacking the healthy cells of the body. This may lead to damage, disease and severe disorders. Antioxidants are substances that neutralize free radicals or their actions. Nature has endowed each cell with adequate protective mechanisms against any harmful effects of free radicals: superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, thioredoxin, thiols and disulfide bonding are buffering systems in every cell. α-Tocopherol (vitamin E) is an essential nutrient which functions as a chain-breaking antioxidant which prevents the propagation of free radical reactions in all cell membranes in the human body. Ascorbic acid (vitamin C) is also part of the normal protecting mechanism. Other non-enzymatic antioxidants include carotenoids, flavonoids and related polyphenols, α-lipoic acid, glutathione etc. This review article summarizes the functional role of reactive oxygen species (ROS), reactive nitrogen species, reactive halogen species and their pathological importance.
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The origin of the name resveratrol is reportedly derived from the Latin word 'res' meaning 'which... more The origin of the name resveratrol is reportedly derived from the Latin word 'res' meaning 'which comes from' the plant 'veratrum' and 'ol' indicating the presence of an alcohol moiety. Resveratrol is obtained from plants. The function of resveratrol in plants is thought to be protection since it is produced when the plant is under environmental stress, whether ultraviolet radiation, infection, or insect infestation. Resveratrol's introduction into the dietary supplement market a few years back was based upon the consideration that intake of it and other polyphenol compounds from red wine may contribute to the ‚French paradox‛, the unexpectedly low rate of death from cardiovascular disease in the Mediterranean population, despite a diet that is relatively high in saturated fat. Since then, interest in resveratrol has increased due to research suggesting additional antioxidant, anti-inflammatory, anticancer, antiviral, and anti-aging effects; as well as possibly playing a role in weight loss and athletic performance. Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowing the aging process and preventing chronic diseases. This review summarizes the ethnopharmacological aspects of resveratrol and provides suggested directions for future research in this realm.
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Papers by PRADEEP PATERIYA
Methodology: Antioxidant activities were determined in vitro by the total phenolic, total flavonoid, ferric reducing antioxidant power (FRAP), DPPH, hydrogen peroxide and ABTS methods. Analgesic and antipyretic activities were investigated using the acetic acid induced writhing and brewer’s yeast induced hyperpyrexia assays respectively.
Results: Ethanol extract had high phenolic (4.15-44.35 mgCA/g) and flavonoid (85.56-596.7 mgCA/g) contents and FRAP (187.87-371.41 mgCA/g). This extract exhibited strong DPPH (IC50 = 0.49 μg/ml), H2O2 (IC50 = 1.62 μg/ml) and ABTS (IC50= 0.43 μg/ml) radical scavenging activities. Significant reduction of abdominal writhing (P<0.001) and fever (P< 0.001) were observed in rats in a dose dependent manner after administration of the ethanol extract with the most effective dose being 400 mg/kg b.w.
Conclusion: These results provide promising baseline information
for the potential use of Dichaetanthera africana in the treatment of pain and fever.
Methodology: Antioxidant activities were determined in vitro by the total phenolic, total flavonoid, ferric reducing antioxidant power (FRAP), DPPH, hydrogen peroxide and ABTS methods. Analgesic and antipyretic activities were investigated using the acetic acid induced writhing and brewer’s yeast induced hyperpyrexia assays respectively.
Results: Ethanol extract had high phenolic (4.15-44.35 mgCA/g) and flavonoid (85.56-596.7 mgCA/g) contents and FRAP (187.87-371.41 mgCA/g). This extract exhibited strong DPPH (IC50 = 0.49 μg/ml), H2O2 (IC50 = 1.62 μg/ml) and ABTS (IC50= 0.43 μg/ml) radical scavenging activities. Significant reduction of abdominal writhing (P<0.001) and fever (P< 0.001) were observed in rats in a dose dependent manner after administration of the ethanol extract with the most effective dose being 400 mg/kg b.w.
Conclusion: These results provide promising baseline information
for the potential use of Dichaetanthera africana in the treatment of pain and fever.