Cadmium accumulation in the lens has been implicated in cataractogenesis of chronic smokers. This... more Cadmium accumulation in the lens has been implicated in cataractogenesis of chronic smokers. This study was planned to evaluate whether or not in vivo cigarette smoke exposure causes cadmium accumulation in rat lens, and possible protective effect and mechanism of alpha-tocopherol (vitamin E) treatment on cataractogenesis. 28 male Wistar rats were randomly divided into four equal groups. Group 3 and 4 rats were exposed to cigarette smoke over ninety consecutive days, and Group 1 and 2 rats were treated in a similar fashion but exposed only to room air. Additionally, vitamin E was given to Group 2 and 4 rats. Significantly higher iron levels were observed in the lenses of Group 3 rats compared to other groups. With respect to cadmium, Group 3 and 4 rats had significantly higher levels compared to Group 1 and 2 rats. Although vitamin E treatment prevented iron accumulation in Group 4 rats, it had no effect on cadmium concentrations. Distinct histopathological changes observed in Group 3 rats were not present in Group 4 rats. Our study demonstrates that in vivo cigarette smoke exposure causes accumulation of cadmium in rat lens and IM vitamin E treatment does not affect this accumulation. The protective effect of vitamin E treatment on smoke exposed rat lens seems to be mediated by blockage of iron accumulation in the lens.
... Dr. Işık Aslay, İstanbul Dr. Lale Atahan, Ankara Dr. Şafak Atahan, Bursa Dr. Güven Atasoy, Bu... more ... Dr. Işık Aslay, İstanbul Dr. Lale Atahan, Ankara Dr. Şafak Atahan, Bursa Dr. Güven Atasoy, BursaDr. Hülya Aydın, İstanbul Dr. Adnan Aydıner, İstanbul Dr. Sabri Barutca, Aydın Dr. Semih Baskan, Ankara Dr. Ataç Baykal, Ankara Dr. Ümit Bayol, İzmir Dr. Uğur Berberoğlu, Ankara ...
Ulcerative colitis is a chronic inflammatory disorder of unknown cause which is only rarely compl... more Ulcerative colitis is a chronic inflammatory disorder of unknown cause which is only rarely complicated by chronic amebic colitis in the western world. The aim of this clinical study was to determine the significiance of p-ANCA positivity in differentiating amebic colitis from ulcerative colitis ...
Mutations in HPGD have recently been reported to cause primary hypertrophic osteoarthropathy (PHO... more Mutations in HPGD have recently been reported to cause primary hypertrophic osteoarthropathy (PHO), a rare genetic disease characterized by digital clubbing, pachydermia, and periostosis. We screened HPGD mutations in six patients from three unrelated Turkish families with PHO, in which we showed one previously reported, p.A140P, and one novel, p.M1L, homozygous mutations. Both mutations co-segregated with the phenotype in all three families and were absent in 100 Turkish controls. These results confirm the presence of biallelic HPGD mutations in patients with PHO in an independent series from a different population.
Cadmium accumulation in the lens has been implicated in cataractogenesis of chronic smokers. This... more Cadmium accumulation in the lens has been implicated in cataractogenesis of chronic smokers. This study was planned to evaluate whether or not in vivo cigarette smoke exposure causes cadmium accumulation in rat lens, and possible protective effect and mechanism of alpha-tocopherol (vitamin E) treatment on cataractogenesis. 28 male Wistar rats were randomly divided into four equal groups. Group 3 and 4 rats were exposed to cigarette smoke over ninety consecutive days, and Group 1 and 2 rats were treated in a similar fashion but exposed only to room air. Additionally, vitamin E was given to Group 2 and 4 rats. Significantly higher iron levels were observed in the lenses of Group 3 rats compared to other groups. With respect to cadmium, Group 3 and 4 rats had significantly higher levels compared to Group 1 and 2 rats. Although vitamin E treatment prevented iron accumulation in Group 4 rats, it had no effect on cadmium concentrations. Distinct histopathological changes observed in Group 3 rats were not present in Group 4 rats. Our study demonstrates that in vivo cigarette smoke exposure causes accumulation of cadmium in rat lens and IM vitamin E treatment does not affect this accumulation. The protective effect of vitamin E treatment on smoke exposed rat lens seems to be mediated by blockage of iron accumulation in the lens.
... Dr. Işık Aslay, İstanbul Dr. Lale Atahan, Ankara Dr. Şafak Atahan, Bursa Dr. Güven Atasoy, Bu... more ... Dr. Işık Aslay, İstanbul Dr. Lale Atahan, Ankara Dr. Şafak Atahan, Bursa Dr. Güven Atasoy, BursaDr. Hülya Aydın, İstanbul Dr. Adnan Aydıner, İstanbul Dr. Sabri Barutca, Aydın Dr. Semih Baskan, Ankara Dr. Ataç Baykal, Ankara Dr. Ümit Bayol, İzmir Dr. Uğur Berberoğlu, Ankara ...
Ulcerative colitis is a chronic inflammatory disorder of unknown cause which is only rarely compl... more Ulcerative colitis is a chronic inflammatory disorder of unknown cause which is only rarely complicated by chronic amebic colitis in the western world. The aim of this clinical study was to determine the significiance of p-ANCA positivity in differentiating amebic colitis from ulcerative colitis ...
Mutations in HPGD have recently been reported to cause primary hypertrophic osteoarthropathy (PHO... more Mutations in HPGD have recently been reported to cause primary hypertrophic osteoarthropathy (PHO), a rare genetic disease characterized by digital clubbing, pachydermia, and periostosis. We screened HPGD mutations in six patients from three unrelated Turkish families with PHO, in which we showed one previously reported, p.A140P, and one novel, p.M1L, homozygous mutations. Both mutations co-segregated with the phenotype in all three families and were absent in 100 Turkish controls. These results confirm the presence of biallelic HPGD mutations in patients with PHO in an independent series from a different population.
Uploads
Papers by Mustafa Turay