Papers by Michele Mondino
BackgroundTocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in patho... more BackgroundTocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.MethodsA multicentre, single-arm, hypothesis-driven phase 2 trial was planned to study the effect of Tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints). A cohort of patients consecutively enrolled after phase 2 was used as a validation dataset. A multivariable logistic regression was performed to generate hypotheses, while controlling for possible confounders.Resultsout of 301 patients in phase 2 intention-to-treat (ITT) analysis, 180 (59.8%) received tocilizumab. With 67 death events, lethality rates were 18.4% (97.5%CI: 13.6-24.0, P=0.52) and 22.4% (97.5%CI: 17.2-28.3, P<0.001) at 14 and 30 days. Lethality rates were lower in the validation dataset, including 920 patients. No signal of specific drug toxicity was reported. The multivariable logistic regression suggests tocilizumab might be...
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Current Anesthesiology Reports
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ECMO-Extracorporeal Life Support in Adults, 2014
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Journal of Cardiothoracic and Vascular Anesthesia, 2011
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Critical Care Medicine, 2005
Methods: On all pts admitted to our ICU since January 1997 through June 2004 we collected (i) dem... more Methods: On all pts admitted to our ICU since January 1997 through June 2004 we collected (i) demographics (ii) Cs operation type and gravity score (CRS, CCS, NYHA)(iii) risk factors and underlying illnesses (iv) ICU and hospital length of stay (v) cardiopulmonary by-pass ( ...
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The Annals of Thoracic Surgery, 2012
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American Journal of Respiratory and Critical Care Medicine, 2001
We aimed to elucidate the relationships between pleural (Ppl), esophageal (Pes), and superimposed... more We aimed to elucidate the relationships between pleural (Ppl), esophageal (Pes), and superimposed gravitational pressures in acute lung injury, and to understand the mechanisms of recruitment and derecruitment. In six dogs with oleic acid respiratory failure, we measured Pes and Ppl in the uppermost, middle, and most dependent lung regions. Each dog was studied at positive end-expiratory pressure (PEEP) of 5 and 15 cm H2O and three levels of tidal volume (VT; low, medium, and high). For each PEEP-VT combination, we obtained a computed tomographic (CT) scan at end-inspiration and end-expiration. The variations of Ppl and Pes pressures were correlated (r = 0.86 +/- 0.07, p &amp;amp;amp;amp;lt; 0.0001), as was the vertical gradient of transpulmonary (PL) and superimposed pressure (r = 0.92, p &amp;amp;amp;amp;lt; 0.0001). Recruitment proceeded continuously along the entire volume-pressure curve. Estimated threshold opening pressures were normally distributed (mode = 20 to 25 cm H2O). The amount of end-expiratory collapse at the same PEEP and PL was significantly lower when ventilation was performed at high VT. End-inspiratory and end-expiratory collapse were highly correlated (r = 0.86, p &amp;amp;amp;amp;lt; 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased.
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International Journal of Cardiology, 2015
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Papers by Michele Mondino