Papers by Marcello Schiavo
Liver Transplantation, 2000
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Data Revues 14702045 V10i1 S1470204508702845, Jul 8, 2011
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Clinical Cancer Research an Official Journal of the American Association For Cancer Research, Aug 1, 2003
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Clinical Cancer Research
ABSTRACT
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Human Pathology, 2003
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Clinical cancer research : an official journal of the American Association for Cancer Research, Jan 15, 2003
Heat shock proteins (HSP) from tumor cells contain the gp96 polypeptide associated with cancer-sp... more Heat shock proteins (HSP) from tumor cells contain the gp96 polypeptide associated with cancer-specific antigenic peptides. Mice that are immunized with HSP/peptide-complex (HSPPC) derived from cancer tissue reject tumor from which HSPs are purified. We tested in humans whether vaccination with HSPPC-gp96 (Oncophage) from autologous liver metastases of colorectal carcinoma induces cancer-specific T-cell responses in patients rendered disease free by surgery. Twenty-nine consecutive patients underwent radical resection of liver metastases [Memorial Sloan-Kettering Cancer Center (MSKCC) score 1-3 (good prognosis), 18 patients; score 4-5 (bad prognosis), 11 patients] and received autologous tumor-derived HSPPC-96. Two vaccine cycles were administered (four weekly injections followed by four biweekly injections after 8 weeks). Class-I HLA-restricted, anti-colon cancer lines T-cell response was measured by ELISPOT assay on peripheral blood mononuclear cells (PBMCs) obtained before and af...
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Transplantation Proceedings, 2007
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Transplantation Proceedings, 2001
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Transplantation Proceedings, 2001
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Transplantation Proceedings, 2001
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Liver Transplantation, 2000
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Liver Transplantation, 2000
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Liver Transplantation, 2000
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Liver Transplantation, 2000
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The Lancet Oncology, 2009
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Journal of Hepatology, 2003
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Journal of Hepatology, 2004
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Journal of Hepatology, 2003
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Journal of Hepatology, 2003
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Hepatology, 2006
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Papers by Marcello Schiavo