An important method used to make medical implants radiologically visible is based on introduction... more An important method used to make medical implants radiologically visible is based on introduction of radiopaque bromine or iodine containing methacrylic monomers. Thus, 2-(2-bromopropionyloxy) propyl methacrylate (BPPM) and 2-(2-bromoisobutyryloxy) propyl methacrylate (BIPM) were synthesized with the aim to use them as radiopaque agents. The free radical initiated copolymerization of BPPM and BIPM with methyl methacrylate (MMA) were performed directly in a thermostatic cell of the NMR spectrometer. The copolymer compositions obtained from
Controlled release of drugs on ocular level is an important care for modern pharmacology. New stu... more Controlled release of drugs on ocular level is an important care for modern pharmacology. New studies targets are medical ophthalmic products with prolonged action (controlled release, target release). The hydrogel is an important segment in these studies. The purpose of this study is to assess a monolithic thermosensible hydrogel for releasing a certain medical product. We used several materials for making thermosensible ophthalmic inserts that were processed (hydrogel synthesis, establish the inflation degree, hydrogel drug inclusion, establish the kinetics of in vitro drug releasing, in vivo studies). The study show that MA-G and PNIPAm basis hydrogel is a smart one that have the ability to collapse on a temperature closed to the physiological one, the result is the drug release in a desired doses. The hydrogel is perfectly tolerated, an experimental study prove that. Controlled release of active drug that are highly adequate to have a clinical response is based on small doses, w...
The new pyrroles 8a,b were obtained by one-pot reaction from N1-quinazolinum bromides and non-sym... more The new pyrroles 8a,b were obtained by one-pot reaction from N1-quinazolinum bromides and non-symmetrical acetylenic dipolarophiles. Structural characterizations were based on IR and NMR spectroscopy as well as on single crystal X-ray diffraction.
Treatment of quinazolin-4(3H)-one bromides with acetylenic dipolarophiles in 1,2-epoxybutane medi... more Treatment of quinazolin-4(3H)-one bromides with acetylenic dipolarophiles in 1,2-epoxybutane medium gave, in good yields, N-arylpyrroles instead of the corresponding pyrrolo[1,2-a] quinazolines. The structures of the pyrroles were deduced by NMR spectroscopy and confirmed by X-ray crystal structure analysis. The (1)H NMR spectra of ethyl esters revealed hindered rotation about the N-Ar bond.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
UPB Scientific Bulletin, Series B: Chemistry and Materials Science
The pyrrolo[2,1-a]phthalazines 6 were obtained by 1,3-dipolar cycloaddition of the corresponding ... more The pyrrolo[2,1-a]phthalazines 6 were obtained by 1,3-dipolar cycloaddition of the corresponding acetylphtalazinium methanide 3 with acetylenic dipolarophiles. The structural variety was achieved by varying the dipolarophiles. The one-pot reaction fits well to the concept of sustainable chemistry.
The title compounds (IV) (7 examples) are regioselectively obtained in a three-component one-pot ... more The title compounds (IV) (7 examples) are regioselectively obtained in a three-component one-pot reaction between pyridazine (I), phenacyl bromides (II), and 1-butyn-3-one (III) in the presence of 1,2-epoxybutane as reaction medium and acid scavenger.
The synthesis of new highly substituted N-arylpyrroles was achieved by 1,3-dipolar cycloaddition ... more The synthesis of new highly substituted N-arylpyrroles was achieved by 1,3-dipolar cycloaddition of the quinazolinium N-ylides with acetylenic dipolarophiles. The reaction was conducted as one-pot procedure in 1,2-epoxybutane as reaction medium and proton scavenger. Structural variety of compounds was conferred by the use of various symmetrical and non-symmetrical acetylenic dipolarophiles. In the case of symmetrical dipolarophiles (i.e. Dimethyl acetylenedicarboxylate) the pyrrolo[1,2-a]quinazoline framework could be isolated and characterized.
UPB Scientific Bulletin, Series B: Chemistry and Materials Science
The quinazolinonium bromides were obtained in good yields by reacting the corresponding quinazoli... more The quinazolinonium bromides were obtained in good yields by reacting the corresponding quinazolinone with brominated derivatives. The compounds could provide a library for further studies on their biological activity.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
This book is a critical and lucid account of various synthetic methodologies and biological activ... more This book is a critical and lucid account of various synthetic methodologies and biological activities of different sized bioactive heterocyclic compounds. In effect, this book imparts a great deal of comprehensive reviews about the chemistry and biology of selected groups of heterocycles and natural products including important pharmaceuticals as well as agrochemical pesticides in one handy project. Besides, this compendious effort encompasses different methods of synthesis and biological evaluation of heterocyclic compounds. The main purpose of this book is to share the recent advances and scope of Bioactive Heterocycles for the future avenues in the field. It has specifically been designed by keeping in mind the wide interests of individuals engaged in the design and synthesis of biologically active heterocyclic compounds as well as research scientists in academia and industry. The authors expect this book to be a standard reference in Universities and industrial libraries.
An important method used to make medical implants radiologically visible is based on introduction... more An important method used to make medical implants radiologically visible is based on introduction of radiopaque bromine or iodine containing methacrylic monomers. Thus, 2-(2-bromopropionyloxy) propyl methacrylate (BPPM) and 2-(2-bromoisobutyryloxy) propyl methacrylate (BIPM) were synthesized with the aim to use them as radiopaque agents. The free radical initiated copolymerization of BPPM and BIPM with methyl methacrylate (MMA) were performed directly in a thermostatic cell of the NMR spectrometer. The copolymer compositions obtained from
Controlled release of drugs on ocular level is an important care for modern pharmacology. New stu... more Controlled release of drugs on ocular level is an important care for modern pharmacology. New studies targets are medical ophthalmic products with prolonged action (controlled release, target release). The hydrogel is an important segment in these studies. The purpose of this study is to assess a monolithic thermosensible hydrogel for releasing a certain medical product. We used several materials for making thermosensible ophthalmic inserts that were processed (hydrogel synthesis, establish the inflation degree, hydrogel drug inclusion, establish the kinetics of in vitro drug releasing, in vivo studies). The study show that MA-G and PNIPAm basis hydrogel is a smart one that have the ability to collapse on a temperature closed to the physiological one, the result is the drug release in a desired doses. The hydrogel is perfectly tolerated, an experimental study prove that. Controlled release of active drug that are highly adequate to have a clinical response is based on small doses, w...
The new pyrroles 8a,b were obtained by one-pot reaction from N1-quinazolinum bromides and non-sym... more The new pyrroles 8a,b were obtained by one-pot reaction from N1-quinazolinum bromides and non-symmetrical acetylenic dipolarophiles. Structural characterizations were based on IR and NMR spectroscopy as well as on single crystal X-ray diffraction.
Treatment of quinazolin-4(3H)-one bromides with acetylenic dipolarophiles in 1,2-epoxybutane medi... more Treatment of quinazolin-4(3H)-one bromides with acetylenic dipolarophiles in 1,2-epoxybutane medium gave, in good yields, N-arylpyrroles instead of the corresponding pyrrolo[1,2-a] quinazolines. The structures of the pyrroles were deduced by NMR spectroscopy and confirmed by X-ray crystal structure analysis. The (1)H NMR spectra of ethyl esters revealed hindered rotation about the N-Ar bond.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
UPB Scientific Bulletin, Series B: Chemistry and Materials Science
The pyrrolo[2,1-a]phthalazines 6 were obtained by 1,3-dipolar cycloaddition of the corresponding ... more The pyrrolo[2,1-a]phthalazines 6 were obtained by 1,3-dipolar cycloaddition of the corresponding acetylphtalazinium methanide 3 with acetylenic dipolarophiles. The structural variety was achieved by varying the dipolarophiles. The one-pot reaction fits well to the concept of sustainable chemistry.
The title compounds (IV) (7 examples) are regioselectively obtained in a three-component one-pot ... more The title compounds (IV) (7 examples) are regioselectively obtained in a three-component one-pot reaction between pyridazine (I), phenacyl bromides (II), and 1-butyn-3-one (III) in the presence of 1,2-epoxybutane as reaction medium and acid scavenger.
The synthesis of new highly substituted N-arylpyrroles was achieved by 1,3-dipolar cycloaddition ... more The synthesis of new highly substituted N-arylpyrroles was achieved by 1,3-dipolar cycloaddition of the quinazolinium N-ylides with acetylenic dipolarophiles. The reaction was conducted as one-pot procedure in 1,2-epoxybutane as reaction medium and proton scavenger. Structural variety of compounds was conferred by the use of various symmetrical and non-symmetrical acetylenic dipolarophiles. In the case of symmetrical dipolarophiles (i.e. Dimethyl acetylenedicarboxylate) the pyrrolo[1,2-a]quinazoline framework could be isolated and characterized.
UPB Scientific Bulletin, Series B: Chemistry and Materials Science
The quinazolinonium bromides were obtained in good yields by reacting the corresponding quinazoli... more The quinazolinonium bromides were obtained in good yields by reacting the corresponding quinazolinone with brominated derivatives. The compounds could provide a library for further studies on their biological activity.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
This book is a critical and lucid account of various synthetic methodologies and biological activ... more This book is a critical and lucid account of various synthetic methodologies and biological activities of different sized bioactive heterocyclic compounds. In effect, this book imparts a great deal of comprehensive reviews about the chemistry and biology of selected groups of heterocycles and natural products including important pharmaceuticals as well as agrochemical pesticides in one handy project. Besides, this compendious effort encompasses different methods of synthesis and biological evaluation of heterocyclic compounds. The main purpose of this book is to share the recent advances and scope of Bioactive Heterocycles for the future avenues in the field. It has specifically been designed by keeping in mind the wide interests of individuals engaged in the design and synthesis of biologically active heterocyclic compounds as well as research scientists in academia and industry. The authors expect this book to be a standard reference in Universities and industrial libraries.
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