Papers by Larysa Paniwnyk
Expert opinion on drug delivery, 2016
Drug delivery pertaining to acoustic cavitation generated from ultrasonic (US) irradiation is adv... more Drug delivery pertaining to acoustic cavitation generated from ultrasonic (US) irradiation is advantageous for devising smarter and more advanced therapeutics. The aim is to showcase microbubbles as drug carriers and robust theranostic for non-invasive therapies across diverse biomedical disciplines, highlighting recent technologies in this field for overcoming the blood-brain barrier (BBB) to treat cancers and neurological disorders. This article reviews work on the optimized tuning of ultrasonic parameters, sonoporation, transdermal and responsive drug delivery, acoustic cavitation in vasculature and oncology, contrast imaging for real-time magnification of cell-microbubble dynamics and biomolecular targeting. Scholarly literature was sought through database search on key terminology, latest topics, reputable experts and established journals over the last five years. Cavitation offers immense promise in overcoming current diffusion and convection limitations for treating skull/bra...
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Journal of Organometallic Chemistry, 1989
ABSTRACT The carbon-13 NMR spectra of twenty four acyclic and cyclic η4-1,3-, 1,4- and 1,5-diene-... more ABSTRACT The carbon-13 NMR spectra of twenty four acyclic and cyclic η4-1,3-, 1,4- and 1,5-diene-rhodium(I) complexes of type η5-C5H4XRh (η4-diene), (X =H, Cl, Ph, CO2CH3 or CHO) are described. Each diene type can be easily distinguished from the values of its 103Rh13C coupling constants and olefincarbon coordination shifts. The effects of methyl substituents on the relative chemical shifts of the acyclic η4-1,3-diene carbon atom are broadly similar to that in analogous η4-dienetricarbonyliron systems, but the metalcarbon coupling constants imply a greater degree of retrodative bonding in the case of the rhodium complexes. The largest coordination shifts are found for the β olefin carbons of the 1,4-diene complexes. The unusual metalcarbon coupling in these complexes are a reflection of the strained conformation adopted on bonding to rhodium, and do not suggest conjugative interaction between the two alkene functions. The spectra of the 1,5-diene complexes show the expected trend resulting from a reduction in strain energy relative to that for the previous case. The spectra of the η5-cyclopentadienyl groups in these complexes as discussed in terms of a small contribution from either an η3-allyl-η2-ene or a η4-diolefin-η1-alkyl rotamer to the metalring bonding scheme; the rotamer type is governed by the cyclopentadienyl ring substituent and counter diene ligand. Several functionally-substituted cyclopentadienide salts have been examined by variable temperature hydrogen-1 and carbon-13 NMR spectroscopy. The fluxional behaviour of Tl1(C5H4NO2 and K(C5H4CHO) demonstrate how the Lewis acid character of the metal ion and the electron-accepting nature of the ring substituent control the structural preference for a form in which the substituent is either co-planar or orthogonal with respect to the cyclopentadienide group. Two dimensional 1H13C NMR spectra and simulation techniques peritted unambiguous assignment of ring nuclei. The chemical ionisation and fast atom bombardment mass spectra of several of the thallium(I) complexes reveal considerable association in the vapour state.
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Journal of Catalysis, 1994
The dehydrogenation of tetrahydronaphthalene to naphthalene using 3% Pd/C in diethylene glycol (d... more The dehydrogenation of tetrahydronaphthalene to naphthalene using 3% Pd/C in diethylene glycol (digol) under the influence of sonication is reported. The conventional reaction in digol at 200[degrees]C reached 55% conversion in 6 h, whereas using sonication at 180[degrees]C, complete reaction could be achieved in the same time. Pulsed ultrasound (at 50% cycle) was as effective as continuous sonication. The activity
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Ultrasonics Sonochemistry, 2001
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Emerging Technologies for Food Processing, 2014
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The Journal of the Acoustical Society of America, 2008
ABSTRACT High power ultrasound at frequencies around 20kHz is capable of killing bacteria and for... more ABSTRACT High power ultrasound at frequencies around 20kHz is capable of killing bacteria and for many years has been standard technique in microbiology for the disruption of living cells to release their contents. So successful is this effect that ultrasound has been studied as a possible method for water disinfection. The energies required for using ultrasound alone are high but commercial equipment is available and is often used for disinfection in conjunction with other techniques such as ozonation or uv irradiation. Now evidence is emerging that is possible to induce effects on bacteria other than kill by modifying the acoustic energy entering the suspension (Ultrason. Sonochem. 10:315, 2003). This can be done by altering the duration of exposure, the acoustic power used or the frequency of the ultrasound. In this way sonication can lead to such effects as deagglommeration, enhanced reaction to biocides and gene transfer (Nucleic Acids Res. 35:e129, 2007).
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Czech journal of food …, 2007
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Polyhedron, 1997
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Physics Procedia, 2010
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Advances in Sonochemistry, 1996
... Similar results were obtained from a study of the effect of sonication on cured rolled ham ..... more ... Similar results were obtained from a study of the effect of sonication on cured rolled ham ... particle size and a narrower size distribution compared with those produced by conventional methodology. ... and is thought to be due to an increase in the number of crystallization nuclei and ...
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Alternatives to Conventional Food Processing, 2010
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Papers by Larysa Paniwnyk