Papers by Juan Gallegos-Orozco
American Journal of Gastroenterology, 2010
Bookmarks Related papers MentionsView impact
Transplantation, May 1, 2017
Bookmarks Related papers MentionsView impact
The Journal of Infectious Diseases, 2004
The dynamics of hepatitis C virus (HCV) quasi species in the E2 region may correlate with the cou... more The dynamics of hepatitis C virus (HCV) quasi species in the E2 region may correlate with the course of infection after orthotopic liver transplantation (OLT). Thirty-four patients who underwent transplantation for HCV-related cirrhosis were studied. Serum and liver samples were available before OLT and at 1 week, 4 months, and 1 year after OLT. Patients were divided into group 1 (Knodell/Ishak fibrosis stage [FS] at 1 year, <2) and group 2 (FS at 1 year, > or =2). Complexity was estimated by the number of bands in a single-strand conformational polymorphism assay, whereas diversity was measured by Shannon entropy (SE) and median mobility shift (MMS) values derived from the heteroduplex mobility assay. Diversity dynamics were measured at transmission (before OLT vs. 1 week after OLT) and after OLT (1 week after OLT vs. 1 year after OLT). Complexity was higher in group 1 patients than in group 2 patients before OLT…
Bookmarks Related papers MentionsView impact
Gastroenterology, 2016
Bookmarks Related papers MentionsView impact
Transplantation of the Liver, 2015
Bookmarks Related papers MentionsView impact
Gastroenterology & hepatology, 2010
By interrupting the adenoma-carcinoma sequence, endo-scopic polypectomy can prevent the developme... more By interrupting the adenoma-carcinoma sequence, endo-scopic polypectomy can prevent the development of colorectal cancer (CRC). Endoscopic polypectomy has, therefore, become an accepted screening and surveillance modality for CRC and has been widely adopted by clinicians, policymakers, and professional organizations as an effective screening tool. Most gastroenterologists are adequately trained to endoscopically excise the majority of polyps found in a routine colonoscopy. However, some polyps, due to their size, location, or configuration, are considered more technically challenging or are associated with an increased risk of complications (such as bleeding or perforation) and, hence, are not routinely resected. These so-called complex polypectomies are the focus of this paper.
Bookmarks Related papers MentionsView impact
Revista de gastroenterología de México
The diagnosis of an autoimmune liver disease is based on clinical, biochemical, immunological and... more The diagnosis of an autoimmune liver disease is based on clinical, biochemical, immunological and histological criteria particular to each disease, such as autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC). Hepatic overlap syndromes (OS) are defined by the presence of a well established autoimmune liver disease, primarily AIH plus two or more characteristics associated with another liver disease (PBC or PSC); however the association of HAI and PSC is considered rare in adult population, and only 43 cases have been reported in the literature. The aim of this study is to review and reappraise the characteristics of this rare association, and to discuss current concepts on OS. We describe the clinical presentation, evolution, radiologic studies, histological characteristics and therapeutic options in a Mexican woman with OS (HAI-PSC). We also include an updated review of the literature. Overlap ofAIH and PSC has been described in a numb...
Bookmarks Related papers MentionsView impact
Liver and Biliary Disease, 2010
Page 1. V PART 5 Diseases of the Liver Practical Gastroenterology and Hepatology: Liver and Bilia... more Page 1. V PART 5 Diseases of the Liver Practical Gastroenterology and Hepatology: Liver and Biliary Disease Edited by Nicholas J. Talley, Keith D. Lindor and Hugo E. Vargas © 2010 Blackwell Publishing Ltd. ISBN: 978-1-405-18275-1 Page 2. 175 18 CHAPTER 18 ...
Bookmarks Related papers MentionsView impact
Gastroenterology and Hepatology
By interrupting the adenoma-carcinoma sequence, endo-scopic polypectomy can prevent the developme... more By interrupting the adenoma-carcinoma sequence, endo-scopic polypectomy can prevent the development of colorectal cancer (CRC). Endoscopic polypectomy has, therefore, become an accepted screening and surveillance modality for CRC and has been widely adopted by clinicians, policymakers, and professional organizations as an effective screening tool. Most gastroenterologists are adequately trained to endoscopically excise the majority of polyps found in a routine colonoscopy. However, some polyps, due to their size, location, or configuration, are considered more technically challenging or are associated with an increased risk of complications (such as bleeding or perforation) and, hence, are not routinely resected. These so-called complex polypectomies are the focus of this paper.
Bookmarks Related papers MentionsView impact
Revista de gastroenterologia de Mexico
Hepatic abscesses can result from foreign body perforation of the gastrointestinal tract. Althoug... more Hepatic abscesses can result from foreign body perforation of the gastrointestinal tract. Although uncommon, reported cases often involve solitary hepatic abscess with no obvious etiology. We describe the case of a 65-year- old female with multiple hepatic abscesses occurring secondary to chicken bone perforation of the sigmoid colon identified on colonoscopy. With prompt diagnosis, the patient was successfully treated with endoscopic removal of the foreign body and broad spectrum antibiotic treatment.
Bookmarks Related papers MentionsView impact
Annals of hepatology
Bookmarks Related papers MentionsView impact
Revista de gastroenterología de México
The present review focuses on the published information published regarding the effects of interf... more The present review focuses on the published information published regarding the effects of interferon alpha therapy on liver fibrosis in patients with chronic liver damage secondary to hepatitis C infection. Data reviewed included results of the in vitro effects of interferon on hepatic cell line cultures with regards to indirect markers of fibrosis, activation of hepatic stellate cells and oxidative stress response. In the clinical arena, there is current clear evidence of a favorable histological outcome in patients with sustained viral response to interferon therapy. For this reason, the current review focuses more on the histological outcomes regarding liver fibrosis in patients who have not attained viral response to therapy (non-responders) or who already have biopsy defined cirrhosis. Data in these patients were analyzed according to the results of objective testing of fibrosis through the assessment of liver biopsy and its change during time, specially because the morbidity ...
Bookmarks Related papers MentionsView impact
Liver International, 2015
ABSTRACT Chronic hepatitis C cirrhosis, with or without hepatocellular carcinoma, is the leading ... more ABSTRACT Chronic hepatitis C cirrhosis, with or without hepatocellular carcinoma, is the leading indication for liver transplantation (LT) in the United States and Europe (1). Post-transplant recurrence of HCV is universal in patients who have detectable HCV RNA at the time of transplantation. In the absence of effective antiviral therapy, recurrence leads to cirrhosis in 10-25% of recipients by the fifth postoperative year and and 25% reduction in long-term patient survival in comparison to other indications for LT (2,3).This article is protected by copyright. All rights reserved.
Bookmarks Related papers MentionsView impact
Revista médica de Chile, 2010
... [ Links ]. 7. Blumberg R, Kelsey P, Perrone T, Dickersin R, Laquaglia M, Ferruci J. Cytomegal... more ... [ Links ]. 7. Blumberg R, Kelsey P, Perrone T, Dickersin R, Laquaglia M, Ferruci J. Cytomegalovirus-and Cryptosporidium-associated acalculous gangrenous cholecystitis. ... [ Links ]. 34. Klein NA, Mabie WC, Shaver DC, Latham PS, Adamec TA, Pinstein ML, Riely CA. ...
Bookmarks Related papers MentionsView impact
Revista de Gastroenterología de México, 2013
Chronic liver disease and/or portal hypertension may be associated with one of the two pulmonary ... more Chronic liver disease and/or portal hypertension may be associated with one of the two pulmonary vascular complications: portopulmonary hypertension and hepatopulmonary syndrome. These pulmonary vascular disorders are notoriously underdiagnosed; however, they have a substantial negative impact on survival and require special attention in order to understand their diagnostic approach and to select the best therapeutic options. Portopulmonary hypertension results from excessive vasoconstriction, vascular remodeling, and proliferative and thrombotic events within the pulmonary circulation that lead to progressive right ventricular failure and ultimately to death. On the other hand, abnormal intrapulmonary vascular dilations, profound hypoxemia, and a wide alveolar-arterial gradient are the hallmarks of the hepatopulmonary syndrome, resulting in difficult-to-treat hypoxemia. The aim of this review is to summarize the latest pathophysiologic concepts, diagnostic approach, therapy, and prognosis of portopulmonary hypertension and hepatopulmonary syndrome, as well as to discuss the role of liver transplantation as a definitive therapy in selected patients with these conditions.
Bookmarks Related papers MentionsView impact
The American Journal of Gastroenterology, 2000
Bookmarks Related papers MentionsView impact
The Journal of Infectious Diseases, 2005
It is unclear whether patients who test positive for anti-hepatitis C virus (HCV) antibodies and ... more It is unclear whether patients who test positive for anti-hepatitis C virus (HCV) antibodies and have normal alanine aminotransferase (ALT) levels remain infected with the virus. Eleven patients who tested positive for anti-HCV antibodies, had persistently normal ALT levels, and tested negative for HCV RNA by commercial test were studied. Serum and peripheral blood mononuclear cells (PBMCs) were collected 2-3 times at 3-6-month intervals, and PBMCs were cultured with phytohemagglutinin and pokeweed mitogen. HCV RNA was detected in serum samples from 6 (55%) and in PBMCs from 11 (100%) patients. Our results suggest that, in asymptomatic patients who test positive for anti-HCV antibodies, small quantities of HCV RNA commonly persist, even in patients who test negative for HCV RNA in serum by commercial tests.
Bookmarks Related papers MentionsView impact
Revista de gastroenterologia de Mexico
Clostridium difficile-associated diarrhea has become one of the most common healthcare-associated... more Clostridium difficile-associated diarrhea has become one of the most common healthcare-associated infections, with significant morbidity and mortality, especially among the elderly in the inpatient setting. The standard approach with metronidazole and vancomycin is not very effective in treating patients with severe colitis and hence other alternatives have been explored. We herein describe the first successful experience of colonoscopic fecal transplant in a case of severe refractory C. difficile pseudomembranous colitis.
Bookmarks Related papers MentionsView impact
American Journal of Transplantation
Bookmarks Related papers MentionsView impact
Archives of medical research, 2007
Hepatitis C represents more than 35% of liver transplant candidates worldwide. Meanwhile, hepatit... more Hepatitis C represents more than 35% of liver transplant candidates worldwide. Meanwhile, hepatitis B continues to be an important cause of end-stage liver disease and hepatocellular carcinoma in Asia and Africa. Recurrent viral liver disease is a significant event after liver transplantation and continues to be one of the main causes of graft dysfunction and loss in the middle and long-term follow-up. Mechanisms of liver reinfection and disease recurrence vary between these two viruses and pre-emptive as well as the therapeutic approaches are different. Hepatitis B patients can be managed with immune globulin immediately after liver transplant and various agents such as nucleotide and nucleoside analogues can be associated. As a result, disease recurrence has been delayed or prevented in these patients. Individuals transplanted for hepatitis C are known to have universal reinfection and a high rate of disease recurrence has been reported in the literature. Strategies to treat hepat...
Bookmarks Related papers MentionsView impact
Uploads
Papers by Juan Gallegos-Orozco