Few low-velocity, low-impact exercise programs have high appeal for all ages and can be done almo... more Few low-velocity, low-impact exercise programs have high appeal for all ages and can be done almost anywhere. One that meets these specifications is tai chi chuan.
Hawaii International Conference on System Sciences, 2005
This paper describes the current state of the OmniSeer system. OmniSeer supports intelligence ana... more This paper describes the current state of the OmniSeer system. OmniSeer supports intelligence analysts in the handling of massive amounts of data, the construction of scenarios, and the management of hypotheses. OmniSeer models analysts with dynamic user models that capture an analyst's context, interests, and preferences, thus enabling more efficient and effective information retrieval. OmniSeer explicitly represents the prior and tacit knowledge of analysts, thus enabling transfer and reuse of such knowledge. Both the user and cognitive models employ a Bayesian network fragment representation, which supports principled probabilistic reasoning and analysis. An independent evaluation of OmniSeer was carried out at NIST and will be used to guide further development.
A method was developed for determination of total Hg in seafood using 10% w/v SnCl2 · 2H2O and co... more A method was developed for determination of total Hg in seafood using 10% w/v SnCl2 · 2H2O and continuous flow CVAAS after microwave decomposition in closed vessels. Seafoods were decomposed with 5 mL HNO3 and 1 mL 1% w/v NaCl at 200 °C, transferred to polypropylene tubes containing 3.5 mL HCl, and diluted to 50 mL with H2O. Standards were prepared in diluent containing 10% v/v HNO3, 7% v/v HCl, and 0.02% w/v NaCl. Potential interference by 22 elements was evaluated. Interference by Se and Au was observed. Stability of standard solutions in HNO3, HCl and NaCl was evaluated. Stabilizing effect of chloride was demonstrated. Results for six reference materials containing 0.0371–1.59 mg/kg Hg were 86–106% of certificate values. Concentrations in 11 varieties of seafood were 0.015–1.78 mg/kg. Average recoveries of inorganic and organic Hg added to seafood were 102% and 99%, respectively; average recoveries from fortified method blanks were 100% and 97%, respectively. The limits of quantitation were 0.0022 and 0.011 mg/kg in seafoods and reference materials, respectively.
Safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of ATR-107, a fully human ... more Safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of ATR-107, a fully human monoclonal anti-IL-21 receptor (IL-21R) antibody, administered as ascending single doses, subcutaneously or intravenously, was evaluated in a placebo-controlled, double-blind trial in healthy subjects. The dose levels were 3-300 mg by SC and 30-120 mg by IV. The most important adverse events were hypersensitivity reactions occurring in three out of six subjects in 300 mg SC cohort and considered as dose limiting toxicity. More than 75% of the subjects who received ATR-107 developed anti-drug antibodies (ADAs), which had no discernible impact on PK or safety. The PK of ATR-107 appeared to be dose -proportional. T1/2 was shorter than typical therapeutic antibodies. Bioavailability of ATR-107 was about 30%. IL-21R occupancy was measured in circulating B cells in the 60 and 120 mg IV cohort. The data indicated that single dose of ATR-107 was able to maximally occupy IL-21Rs through at least Day 42. Further escalation in the FIH study was halted partially due to the high rates of ADA formation. In conclusion, ATR-107 had a prolonged PD effect measured by IL-21R occupancy; was highly immunogenic after single dose administration and had PK properties with rapid clearance and low bioavailability.
Few low-velocity, low-impact exercise programs have high appeal for all ages and can be done almo... more Few low-velocity, low-impact exercise programs have high appeal for all ages and can be done almost anywhere. One that meets these specifications is tai chi chuan.
Hawaii International Conference on System Sciences, 2005
This paper describes the current state of the OmniSeer system. OmniSeer supports intelligence ana... more This paper describes the current state of the OmniSeer system. OmniSeer supports intelligence analysts in the handling of massive amounts of data, the construction of scenarios, and the management of hypotheses. OmniSeer models analysts with dynamic user models that capture an analyst's context, interests, and preferences, thus enabling more efficient and effective information retrieval. OmniSeer explicitly represents the prior and tacit knowledge of analysts, thus enabling transfer and reuse of such knowledge. Both the user and cognitive models employ a Bayesian network fragment representation, which supports principled probabilistic reasoning and analysis. An independent evaluation of OmniSeer was carried out at NIST and will be used to guide further development.
A method was developed for determination of total Hg in seafood using 10% w/v SnCl2 · 2H2O and co... more A method was developed for determination of total Hg in seafood using 10% w/v SnCl2 · 2H2O and continuous flow CVAAS after microwave decomposition in closed vessels. Seafoods were decomposed with 5 mL HNO3 and 1 mL 1% w/v NaCl at 200 °C, transferred to polypropylene tubes containing 3.5 mL HCl, and diluted to 50 mL with H2O. Standards were prepared in diluent containing 10% v/v HNO3, 7% v/v HCl, and 0.02% w/v NaCl. Potential interference by 22 elements was evaluated. Interference by Se and Au was observed. Stability of standard solutions in HNO3, HCl and NaCl was evaluated. Stabilizing effect of chloride was demonstrated. Results for six reference materials containing 0.0371–1.59 mg/kg Hg were 86–106% of certificate values. Concentrations in 11 varieties of seafood were 0.015–1.78 mg/kg. Average recoveries of inorganic and organic Hg added to seafood were 102% and 99%, respectively; average recoveries from fortified method blanks were 100% and 97%, respectively. The limits of quantitation were 0.0022 and 0.011 mg/kg in seafoods and reference materials, respectively.
Safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of ATR-107, a fully human ... more Safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of ATR-107, a fully human monoclonal anti-IL-21 receptor (IL-21R) antibody, administered as ascending single doses, subcutaneously or intravenously, was evaluated in a placebo-controlled, double-blind trial in healthy subjects. The dose levels were 3-300 mg by SC and 30-120 mg by IV. The most important adverse events were hypersensitivity reactions occurring in three out of six subjects in 300 mg SC cohort and considered as dose limiting toxicity. More than 75% of the subjects who received ATR-107 developed anti-drug antibodies (ADAs), which had no discernible impact on PK or safety. The PK of ATR-107 appeared to be dose -proportional. T1/2 was shorter than typical therapeutic antibodies. Bioavailability of ATR-107 was about 30%. IL-21R occupancy was measured in circulating B cells in the 60 and 120 mg IV cohort. The data indicated that single dose of ATR-107 was able to maximally occupy IL-21Rs through at least Day 42. Further escalation in the FIH study was halted partially due to the high rates of ADA formation. In conclusion, ATR-107 had a prolonged PD effect measured by IL-21R occupancy; was highly immunogenic after single dose administration and had PK properties with rapid clearance and low bioavailability.
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