Papers by Giuseppe Iacono
Journal of Pediatric Gastroenterology and Nutrition, Feb 1, 2000
Cow's milk allergy (CMA) and gastroesophageal reflux are considered to be among the most ... more Cow's milk allergy (CMA) and gastroesophageal reflux are considered to be among the most common disturbances in infants less than 1 year of age. In recent years, the relationship existing between these two entities has been investigated and some important conclusions have been reached: In just under half the cases of GER in infants less than 1 year of age there is an association with CMA; in a high proportion of cases, GER is not only CMA-associated but also CMA-induced; the frequency of this association should induce pediatricians to screen for possible concomitant CMA in all infants with GER less than 1 year old; with the exception of some patients with mild typical CMA manifestations (diarrhea, dermatitis, or rhinitis), the symptoms of GER associated with CMA are the same as those observed in primary GER; immunologic tests are useful in a suspected association between GER and CMA; and subjects with GER secondary to CMA show a typical pH-monitoring tracing pattern, characterized by a progressive, slow decrease in esophageal pH between feedings. This article reviews the main features of the two diseases, stressing the aspects in common between them and comments on all the listed points.
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Scand J Gastroenterol, 2006
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American Journal of Clinical Nutrition
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American Journal of Gastroenterology, 2003
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ABSTRACT Export Date: 10 June 2013, Source: Scopus
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Scandinavian Journal of Gastroenterology, 2006
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Pediatric Research, 1988
ABSTRACT During 1985-86, a nation-wide survey was conducted to assess: 1. Prevalence of acute dia... more ABSTRACT During 1985-86, a nation-wide survey was conducted to assess: 1. Prevalence of acute diarrhoea in 1-3 years old children; 2. Etiology and clinical characteristics of acute-onset diarrhoea in children of 1 month to 14 years of age. METHODS: 1. A cohort of 457 healthy children of 1-24 months of age from 3 towns (Milano, Napoli, Messina) was selected accordingly to criteria that made them representative of the town population and perspectively followed at by-weekly intervals for 1 year. 2. 736 children of 1 month to 14 years of age with acute-onset diarrhoea and presenting for care (567 as inpatients) at the 6 participating pediatric Centers (Milano, Mantova, Roma, Napoli, Messina and Palermo) were enrolled and their stools were looked for rotaviral infection (ELISA test), routine microbiology and osmolality and electrolytes. RESULTS: 1) 266 of the 457 healthy young children (58.2%) showed at least one episode of diarrhea during a 12 months follow-up. The number of episodes significantly differed among different towns, and correlated with the social status. 2) Rotavirus was the most common pathogen (30.8%) followed by Salmonella (10.1%) and Campylobacter (6.0%). In 50 of 241 patients in which both stool osmolality and electrolytes were measured (20.8%), diarrhoea was found to be of secretory type; in the remaining, an osmolar-type diarrhoea was present. Mean duration of diarrhoea was 4.1 days. In 25 casos out of 736 (3.4%) it became protracted (>14 days): previous or early use of antibiotics, food intolerances and Rotavirus infections were all found to be significantly more frequent in patients running a protracted course.
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Nutrients, 2013
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New England Journal of Medicine, 1999
To the Editor: We physicians and Medicare have a shared responsibility for the nearly $20 bil... more To the Editor: We physicians and Medicare have a shared responsibility for the nearly $20 billion that will be spent in 1999 for evaluation and management services. The article by Brett (Dec. 3 issue)1 on new guidelines for coding physicians' services and the accompanying ...
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Journal of Pediatric Gastroenterology and Nutrition, 2000
Cow's milk allergy (CMA) and gastroesophageal reflux are considered to be among the most ... more Cow's milk allergy (CMA) and gastroesophageal reflux are considered to be among the most common disturbances in infants less than 1 year of age. In recent years, the relationship existing between these two entities has been investigated and some important conclusions have been reached: In just under half the cases of GER in infants less than 1 year of age there is an association with CMA; in a high proportion of cases, GER is not only CMA-associated but also CMA-induced; the frequency of this association should induce pediatricians to screen for possible concomitant CMA in all infants with GER less than 1 year old; with the exception of some patients with mild typical CMA manifestations (diarrhea, dermatitis, or rhinitis), the symptoms of GER associated with CMA are the same as those observed in primary GER; immunologic tests are useful in a suspected association between GER and CMA; and subjects with GER secondary to CMA show a typical pH-monitoring tracing pattern, characterized by a progressive, slow decrease in esophageal pH between feedings. This article reviews the main features of the two diseases, stressing the aspects in common between them and comments on all the listed points.
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Journal of Pediatric Gastroenterology and Nutrition, 2006
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Journal of Oral Pathology & Medicine, 2008
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Journal of Crohn's and Colitis, 2009
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Gastroenterology, 2001
Gastroenterology, Volume 120, Issue 5, Pages A391, April 2001, Authors:Sandro Drago;Cristina Alai... more Gastroenterology, Volume 120, Issue 5, Pages A391, April 2001, Authors:Sandro Drago;Cristina Alaimo; Maria Rosaria di Plerro; Fabiola Fornaroli; Tania Gerarduzzi; Gluseppe Iacono; Nicola Locorotondo; Karoly Horvath; Alessio Fasano. ...
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Gastroenterology, 2009
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Digestive and Liver Disease, 2008
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Digestive and Liver Disease, 2008
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Digestive and Liver Disease, 2011
Natural or induced variations in the noxiousness of gluten proteins for celiac disease (CD) patie... more Natural or induced variations in the noxiousness of gluten proteins for celiac disease (CD) patients are currently being investigated for their potential in breeding wheat crops with reduced toxicity. We evaluated the bread wheat line C173 for its effects on the in vitro-grown duodenal mucosa of CD patients. In vitro-grown duodenal mucosa biopsies of 19 CD patients on a gluten-free diet were exposed to peptic/tryptic-digested prolamins from bread wheat line C173 lacking gliadin-glutenin subunits, analyzed for morphology, cytokine and anti-tTG antibody production, and compared with mucosa biopsies exposed to prolamins from wild-type cv. San Pastore. Duodenal mucosa biopsies exposed to prolamins from C173 and San Pastore released higher amounts of IFN-γ, IL-2, IL-10 and anti-tTG antibodies in the culture medium than untreated controls. The line C173 differed from cv. San Pastore as it did not produce negative effects on enterocyte height, suggesting that manipulating prolamin composition can affect innate immune responses of CD mucosa to wheat gluten. Our data demonstrated that this gliadin-deficient wheat has a lower direct toxicity but activates an immunologic reaction of the duodenal mucosa like that of the common wheat species.
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Papers by Giuseppe Iacono